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Prostaglandins Leukot Essent Fatty Acids

Title:		"An open-label, multicenter, phase 2 study of a food enriched with docosahexaenoic acid in adults with sickle cell disease"
Author(s):		Giriraja KV; Bhatnagar SK; Tomlinson L; Sancilio F;
Address:		"Rajalakshmi Hospital & Research Centre, Bangalore, Karnataka, 560097, India. Abhinav Multi-specialty Hospital, Nagpur, Maharashtra, 440017, India. Sancilio & Company, Inc. Stuart, Florida, 34997, United States of America. Sancilio & Company, Inc. Stuart, Florida, 34997, United States of America; Florida Atlantic University, Boca Raton, Florida, 33431, United States of America. Electronic address: fredsancilio@clearwayglobal.com"
Journal Title:		Prostaglandins Leukot Essent Fatty Acids
Year:		2023
Volume:		20230407
Issue:
Page Number:		102574 -
DOI:		10.1016/j.plefa.2023.102574
ISSN/ISBN:		1532-2823 (Electronic) 0952-3278 (Linking)
Abstract:		"Sickle cell disease (SCD) induces red blood cell sickling, which causes debilitating symptoms including vaso-occlusion and inflammation. We investigated a food enriched with omega-3 fatty acids to determine its effect on certain factors: blood cell membrane fatty acid composition (including anti-inflammatory elements-docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)-and the pro-inflammatory, arachidonic acid (AA)); the inflammation biomarker, C-reactive protein (CRP); and vaso-occlusive crisis (VOC) pain. Ten adults with SCD ingested the food, daily, for 28 days. Evaluated measures included blood cell membrane fatty acid ratios (AA vs omega-3 (DHA+EPA)), CRP (mg/L) levels, and Visual Analogue Scale (VAS) scores (a VOC assessment). The food was well tolerated and led to a statistically significant CRP reduction (39%). However, changes in omega-3 fatty acid ratios and VAS scores were not significant. Overall, while the omega-3-enriched food reduced inflammation, larger, blinded studies are needed to assess its effectiveness on other measures"
Keywords:		"Adult Humans Docosahexaenoic Acids *Volatile Organic Compounds *Fatty Acids, Omega-3 *Anemia, Sickle Cell Eicosapentaenoic Acid C-Reactive Protein/metabolism Inflammation Fatty Acids Arachidonic Acid C-reactive protein Docosahexanoic acid Omega-3 fatty ac;"
Notes:		"MedlineGiriraja, K V Bhatnagar, S K Tomlinson, L Sancilio, F eng Clinical Trial, Phase II Multicenter Study Research Support, Non-U.S. Gov't Scotland 2023/05/01 Prostaglandins Leukot Essent Fatty Acids. 2023 Jun; 193:102574. doi: 10.1016/j.plefa.2023.102574. Epub 2023 Apr 7"