| Title: | Organization and regulation of mitogen-activated protein kinase signaling pathways |
| Author(s): | Garrington TP; Johnson GL; |
| Address: | "Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. garringtont@njc.org" |
| DOI: | 10.1016/s0955-0674(99)80028-3 |
| ISSN/ISBN: | 0955-0674 (Print) 0955-0674 (Linking) |
| Abstract: | "Mitogen-activated protein kinases (MAPKs) are components of a three kinase regulatory cascade. There are multiple members of each component family of kinases in the MAPK module. Specificity of regulation is achieved by organization of MAPK modules, in part, by use of scaffolding and anchoring proteins. Scaffold proteins bring together specific kinases for selective activation, sequestration and localization of signaling complexes. The recent elucidation of scaffolding mechanisms for MAPK pathways has begun to solve the puzzle of how specificity in signaling can be achieved for each MAPK pathway in different cell types and in response to different stimuli. As new MAPK members are defined, determining their organization in kinase modules will be critical in understanding their select role in cellular regulation" |
| Keywords: | "*Adaptor Proteins, Signal Transducing Animals Caenorhabditis elegans/physiology Calcium-Calmodulin-Dependent Protein Kinases/*physiology Carrier Proteins/physiology Cell Compartmentation Cell Differentiation/physiology Drosophila melanogaster/physiology F;" |
| Notes: | "MedlineGarrington, T P Johnson, G L eng Review England 1999/04/21 Curr Opin Cell Biol. 1999 Apr; 11(2):211-8. doi: 10.1016/s0955-0674(99)80028-3" |
