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Horm Behav

Title:		Methoprene-tolerant and Kruppel homolog 1 are actors of juvenile hormone-signaling controlling the development of male sexual behavior in the moth Agrotis ipsilon
Author(s):		Aguilar P; Bourgeois T; Maria A; Couzi P; Demondion E; Bozzolan F; Gassias E; Force E; Debernard S;
Address:		"Institute of Biology, University of Madrid, Pozuelo de Alarcon, 28223 Madrid, Spain. Sorbonne Universite, INRA, CNRS, UPEC, IRD, Univ. P7, Institute of Ecology and Environmental Sciences of Paris, 78026 Versailles, France. Sorbonne Universite, INRA, CNRS, UPEC, IRD, Univ. P7, Institute of Ecology and Environmental Sciences of Paris, 75005 Paris, France. Sorbonne Universite, INRA, CNRS, UPEC, IRD, Univ. P7, Institute of Ecology and Environmental Sciences of Paris, 75005 Paris, France. Electronic address: stephane.debernard@sorbonne-universite.fr"
Journal Title:		Horm Behav
Year:		2023
Volume:		20230213
Issue:
Page Number:		105330 -
DOI:		10.1016/j.yhbeh.2023.105330
ISSN/ISBN:		1095-6867 (Electronic) 0018-506X (Linking)
Abstract:		"In insects, juvenile hormone (JH) is critical for the orchestration of male reproductive maturation. For instance, in the male moth, Agrotis ipsilon, the behavioral response and the neuronal sensitivity within the primary olfactory centers, the antennal lobes (ALs), to the female-emitted sex pheromone increase with fertility during adulthood and the coordination between these events is governed by JH. However, the molecular basis of JH action in the development of sexual behavior remains largely unknown. Here, we show that the expression of the paralogous JH receptors, Methoprene-tolerant 1 and 2 (Met1, Met2) and of the JH-inducible transcription factor, Kruppel homolog 1 (Kr-h1) within ALs raised from the third day of adult life and this dynamic is correlated with increased behavioral responsiveness to sex pheromone. Met1-, Met2- and Kr-h1-depleted sexually mature males exhibited altered sex pheromone-guided orientation flight. Moreover, injection of JH-II into young males enhanced the behavioral response to sex pheromone with increased AL Met1, Met2 and Kr-h1 mRNA levels. By contrast, JH deficiency suppressed the behavioral response to sex pheromone coupled with reduced AL Met1, Met2 and Kr-h1 mRNA levels in allatectomized old males and these inhibitions were compensated by an injection of JH-II in operated males. Our results demonstrated that JH acts through Met-Kr-h1 signaling pathway operating in ALs, to promote the pheromone information processing and consequently the display of sexual behavior in synchronization with fertility to optimize male reproductive fitness. Thus, this study provides insights into the molecular mechanisms underlying the hormonal regulation of reproductive behavior in insects"
Keywords:		"Animals Male Female Methoprene/pharmacology *Moths/physiology *Sex Attractants/pharmacology/metabolism Juvenile Hormones/pharmacology/metabolism Signal Transduction RNA, Messenger Agrotis ipsilon Antennal lobe Juvenile hormone signaling Kruppel homolog 1;"
Notes:		"MedlineAguilar, Paleo Bourgeois, Thomas Maria, Annick Couzi, Philippe Demondion, Elodie Bozzolan, Francoise Gassias, Edmundo Force, Evan Debernard, Stephane eng Review 2023/02/16 Horm Behav. 2023 Apr; 150:105330. doi: 10.1016/j.yhbeh.2023.105330. Epub 2023 Feb 13"