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FEBS Lett

Title:		Signaling regulated endocytosis and exocytosis lead to mating pheromone concentration dependent morphologies in yeast
Author(s):		Chou CS; Moore TI; Chang SD; Nie Q; Yi TM;
Address:		"Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA. Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA. Department of Developmental and Cell Biology, University of California at Irvine, Irvine, CA 92697, USA. Department of Mathematics, University of California at Irvine, Irvine, CA 92697, USA. Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA"
Journal Title:		FEBS Lett
Year:		2012
Volume:		20121027
Issue:		23
Page Number:		4208 - 4214
DOI:		10.1016/j.febslet.2012.10.024
ISSN/ISBN:		1873-3468 (Electronic) 0014-5793 (Print) 0014-5793 (Linking)
Abstract:		"Polarized cell morphogenesis requires actin cytoskeleton rearrangement for polarized transport of proteins, organelles and secretory vesicles, which fundamentally underlies cell differentiation and behavior. During yeast mating, Saccharomyces cerevisiae responds to extracellular pheromone gradients by extending polarized projections, which are likely maintained through vesicle transport to (exocytosis) and from (endocytosis) the membrane. We experimentally demonstrate that the projection morphology is pheromone concentration-dependent, and propose the underlying mechanism through mathematical modeling. The inclusion of membrane flux and dynamically evolving cell boundary into our yeast mating signaling model shows good agreement with experimental measurements, and provides a plausible explanation for pheromone-induced cell morphology"
Keywords:		"Endocytosis/*physiology Exocytosis/*physiology Models, Theoretical Pheromones/*metabolism Saccharomyces cerevisiae/*metabolism/*physiology;"
Notes:		"MedlineChou, Ching-Shan Moore, Travis I Chang, Steven D Nie, Qing Yi, Tau-Mu eng R01 GM067247/GM/NIGMS NIH HHS/ T32 HD060555/HD/NICHD NIH HHS/ HD060555-01/HD/NICHD NIH HHS/ P50 GM076516/GM/NIGMS NIH HHS/ R01 GM67247/GM/NIGMS NIH HHS/ P50 GM76516/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. England 2012/10/31 FEBS Lett. 2012 Nov 30; 586(23):4208-4214. doi: 10.1016/j.febslet.2012.10.024. Epub 2012 Oct 27"