| Title: | Volatile organic compounds of possible microbial origin and their risks on childhood asthma and allergies within damp homes |
| Author(s): | Choi H; Schmidbauer N; Bornehag CG; |
| Address: | "Department of Environmental Health Sciences, University at Albany, School of Public Health, State University of New York, United States. Electronic address: hchoi@albany.edu. Norwegian Institute for Air Research, PO Box 100, 2027 Kjeller, Instituttveien 18, 2007 Kjeller, Norway. Electronic address: ns@nilu.no. Technical Research Institute of Sweden, Box 857, SE-501 15 Boras, Sweden; Department of Public Health Sciences, Karlstad University, SE-651 88 Karlstad, Sweden. Electronic address: Carl-Gustaf.Bornehag@kau.se" |
| DOI: | 10.1016/j.envint.2016.10.028 |
| ISSN/ISBN: | 1873-6750 (Electronic) 0160-4120 (Linking) |
| Abstract: | "BACKGROUND: Risk of indoor exposure to volatile organic compounds of purported microbial origin on childhood symptoms of wheezing, rhinitis, and/or eczema, and doctor-diagnosed asthma, rhinitis, and eczema, respectively, remain unclear. OBJECTIVE: To test hypotheses that total sum of 28 microbial volatile organic compounds (Sigma26 MVOCs): 1) poses independent risk on doctor-diagnosed asthma, rhinitis, and eczema, respectively, as well as multiple symptom presentation with a minimum of the two of the above conditions (i.e. case); 2) is associated with significant interaction with absolute humidity (AH) on additive scale. METHODS: In a case-control investigation, 198 cases and 202 controls were examined during November 2001 - March 2002 period through home indoor air sampling, air quality inspection, and health outcome ascertainment. RESULTS: Not only the Sigma28 MVOCs but also the global MVOC index were significantly higher within the homes of the cases with a high AH, compared to the controls with a low AH (all Ps<0.001). Only the cases, but not the controls, were associated with a dose-dependent increase in the exposure variables of interest (Sigma28 MVOCs) per quartile increase in AH (P<0.0001 for the cases; P=0.780 for the controls). Only among the children who live in a high AH homes, a natural log (ln)-unit of Sigma 28 MVOCs was associated with 2.5-times greater odds of the case status (95% CI, 1.0-6.2; P=0.046), compared to 0.7-times the odds (95% CI, 0.4-1.0; P=0.074) of the same outcome among the low AH homes. Specifically, joint exposure to a high MVOCs and high AH was associated with 2.6-times greater odds of the doctor-diagnosed asthma status (95% CI, 0.7-8.91; P=0.137). CONCLUSION: Joint occurrence of high Sigma28 MVOCs and AH was associated with a significant increase in the case status and asthma risks in an additive scale" |
| Keywords: | "Air Pollution, Indoor/*adverse effects/analysis Asthma/*chemically induced Case-Control Studies Child Eczema/etiology Female Fungi/*chemistry Humans Humidity Hypersensitivity/*etiology Male Respiratory Sounds/etiology Risk Volatile Organic Compounds/*adve;" |
| Notes: | "MedlineChoi, Hyunok Schmidbauer, Norbert Bornehag, Carl-Gustaf eng T32 ES007069/ES/NIEHS NIH HHS/ Netherlands 2016/11/14 Environ Int. 2017 Jan; 98:143-151. doi: 10.1016/j.envint.2016.10.028. Epub 2016 Nov 9" |
