| Title: | Prenatal TVOCs exposure negatively influences postnatal neurobehavioral development |
| Author(s): | Chang M; Lee D; Park H; Ha M; Hong YC; Kim Y; Kim BN; Kim Y; Lim YH; Ha EH; |
| Address: | "Department of Preventive Medicine and Medical Research Institute, School of Medicine, Ewha Womans University, South Korea. Department of Mathematics and Statistics, Williams College, USA. Department of Preventive Medicine, Dankook University College of Medicine, South Korea. Department of Preventive Medicine, Seoul National University College of Medicine, South Korea. Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, South Korea. Division of Child & Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, South Korea. Department of Child and Adolescent Psychiatry, National Center for Mental Health, South Korea. Environmental Health Center, Seoul National University College of Medicine, South Korea. Department of Occupational and Environmental Medicine and Medical Research Institute, School of Medicine, Ewha Womans University, South Korea. Electronic address: eunheeha@ewha.ac.kr" |
| DOI: | 10.1016/j.scitotenv.2017.09.046 |
| ISSN/ISBN: | 1879-1026 (Electronic) 0048-9697 (Linking) |
| Abstract: | "Prenatal exposure to volatile organic compounds may restrict fetal development and adversely influence infants' life. Therefore, we investigated the relationship between prenatal exposure to total volatile organic compounds (TVOC) and postnatal neurobehavioral development. A subsample of 383 pregnant participants was chosen from the prospective birth cohort study of Mother and Children's Environmental Health Study; MOCEH (N=1,751) from three regions of the Republic of Korea (Seoul, Cheon-an, and Ulsan). Participants were enrolled during their first trimester with informed consent. We investigated maternal characteristics including socio-economic and obstetrical history using questionnaires. An environmental hygienist measured participating mothers' personal TVOC exposure using passive samplers during pregnancy. Participants visited the research center at 6, 12, 24 and 36 months. At each visit, questionnaires about infantile environment and health conditions were answered and a neurobehavioral test (BSID-II) was conducted by certified investigators. We conducted multiple general linear and mixed model analyses to investigate the relationship between TVOC and infantile neurobehavioral development (SAS 9.3). Mean prenatal TVOC exposure was 284.2mug/m(3). In longitudinal analyses on infantile neurobehavioral development, adjusted mean psychomotor development index and mental developmental index scores in high TVOC exposure group (cut off at Q3: 374.0 ug/m3) were 3 points lower than the low exposure group. Results suggested exposure to higher TVOC during the fetal period may adversely influence neurobehavioral development in the early life stage" |
| Keywords: | "Adult Child Development/*drug effects Child, Preschool Female Humans Infant Maternal Exposure/*adverse effects Pregnancy Prenatal Exposure Delayed Effects/*physiopathology Prospective Studies Republic of Korea Seoul Volatile Organic Compounds/*adverse eff;" |
| Notes: | "MedlineChang, Moonhee Lee, Dongheon Park, Hyesook Ha, Mina Hong, Yun-Chul Kim, Yangho Kim, Boong-Nyun Kim, Yeni Lim, Youn-Hee Ha, Eun-Hee eng Netherlands 2017/11/21 Sci Total Environ. 2018 Mar 15; 618:977-981. doi: 10.1016/j.scitotenv.2017.09.046. Epub 2017 Nov 16" |
