« Previous AbstractOverexpression of eIF4E in Saccharomyces cerevisiae causes slow growth and decreased alpha-factor response through alterations in CLN3 expression    Next Abstract"Two-dimensional gas chromatography/mass spectrometry, physical property modeling and automated production of component maps to assess the weathering of pollutants" »

Anal Chem

Title:		Vacuum Ultraviolet Spectroscopy and Mass Spectrometry: A Tandem Detection Approach for Improved Identification of Gas Chromatography-Eluting Compounds
Author(s):		Anthony IGM; Brantley MR; Gaw CA; Floyd AR; Solouki T;
Address:		"Department of Chemistry and Biochemistry , Baylor University , Waco , Texas 76706 , United States"
Journal Title:		Anal Chem
Year:		2018
Volume:		20180322
Issue:		7
Page Number:		4878 - 4885
DOI:		10.1021/acs.analchem.8b00531
ISSN/ISBN:		1520-6882 (Electronic) 0003-2700 (Linking)
Abstract:		"For wide class characterizations of volatile organic compounds (VOCs), conventional gas chromatography mass spectrometry (GC-MS)-based techniques are utilized. These GC-MS-based chemical identification approaches typically rely on library searches against ion fragmentation patterns of known compounds. Although MS library searches can often provide correct chemical identities, erroneous chemical assignments of structurally similar unknown compounds are also possible. Other detection systems, such as absorption spectrometers, have been used for VOC analysis and can provide complementary absorption data. Here, we demonstrate the analytical advantages of coupling vacuum ultraviolet (VUV) absorption spectroscopy and MS in tandem for the improved characterization of structurally similar VOCs. We also discuss technical considerations and limitations of coupling a VUV spectrometer to a quadrupole mass spectrometer. Moreover, we show that combining the isomer selectivity of VUV spectroscopy, as a nondestructive analyte detection approach, with the mass selectivity of MS in a VUV-MS detection system improves characterization of GC-eluting compounds. Utilizing GC/VUV-MS data, we demonstrate that orthogonal VUV and MS library searches improve identification of VOCs present in complex mixtures such as a mixed standard sample, a commercial perfume product, and an essential oil sample"
Keywords:
Notes:		"PubMed-not-MEDLINEAnthony, Ian G M Brantley, Matthew R Gaw, Christina A Floyd, Adam R Solouki, Touradj eng Research Support, U.S. Gov't, Non-P.H.S. 2018/03/06 Anal Chem. 2018 Apr 3; 90(7):4878-4885. doi: 10.1021/acs.analchem.8b00531. Epub 2018 Mar 22"