« Previous Abstract"Knockout of tyramine receptor 1 results in a decrease of oviposition, mating, and sex pheromone biosynthesis in female Plutella xylostella"    Next AbstractEffects of low frequency ultrasonic treatment on the maturation of steeped greengage wine »

FEBS Lett

Title:		"Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family"
Author(s):		Zheng X; Chen X;
Address:		"CB-2803, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA"
Journal Title:		FEBS Lett
Year:		2001
Volume:		489
Issue:		1
Page Number:		4 - 7
DOI:		10.1016/s0014-5793(00)02437-6
ISSN/ISBN:		0014-5793 (Print) 0014-5793 (Linking)
Abstract:		"p73, a member of the p53 family, has been shown to exhibit similar biochemical activities to that of p53. However, in contrast to p53, p73 is rarely mutated in human tumors and p73 mutant mice develop neurological, pheromonal, and inflammatory defects, but not spontaneous tumors. Furthermore, p73 mutant mice are deficient in the physiological control of cerebral spinal fluid. To determine what mediates these p73 activities, cDNA subtraction assay was performed to identify cellular genes that are regulated by p73. We found that aquaporin 3 (AQP3), a glycerol and water transporter, is regulated by p73. In addition, we identified a potential p53 response element in the promoter of the AQP3 gene, which is responsive to p73. This suggests that AQP3 may mediate the activity of p73 in maintaining cerebral spinal fluid dynamics"
Keywords:		"Aquaporin 3 Aquaporins/*genetics/metabolism Biological Transport DNA, Complementary/analysis DNA-Binding Proteins/*physiology *Gene Expression Regulation Genes, Tumor Suppressor Glycerol/*metabolism Humans Nuclear Proteins/*physiology RNA, Messenger/metab;"
Notes:		"MedlineZheng, X Chen, X eng R01 CA81237/CA/NCI NIH HHS/ Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. England 2001/03/07 FEBS Lett. 2001 Jan 26; 489(1):4-7. doi: 10.1016/s0014-5793(00)02437-6"