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J Hazard Mater

Title:		"Melatonin ameliorates ochratoxin A induced liver inflammation, oxidative stress and mitophagy in mice involving in intestinal microbiota and restoring the intestinal barrier function"
Author(s):		Zhang H; Yan A; Liu X; Ma Y; Zhao F; Wang M; Loor JJ; Wang H;
Address:		"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR China. Department of Animal Sciences and Division of Nutritional Sciences, Urbana, IL 61801, USA. Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR China. Electronic address: hrwang@yzu.edu.cn"
Journal Title:		J Hazard Mater
Year:		2021
Volume:		20201209
Issue:
Page Number:		124489 -
DOI:		10.1016/j.jhazmat.2020.124489
ISSN/ISBN:		1873-3336 (Electronic) 0304-3894 (Linking)
Abstract:		"The mycotoxin ochratoxin A (OTA) is a widespread contaminant in human and animal food products. Previous studies in rats revealed that melatonin (Mel) exhibits a preventive effect against OTA-induced oxidative stress in liver. However, it remains unknown whether gut microbiota respond to Mel and, if so, whether it can prevent OTA-induced inflammation and mitophagy in the liver. In the present study, mice received an oral gavage of Mel and OTA for 3 weeks before harvesting colonic digesta and liver tissue for analyses. In another study, the role of intestinal microbiota on the effects of Mel on OTA-induced liver inflammation and mitophagy was assessed through clearance of intestinal microbiota with antibiotics followed by gut microbiota transplantation (GMT). Oral Mel supplementation ameliorated mitophagy in the liver and reversed gut microbiota dysbiosis. Intriguingly, in antibiotic-treated mice, Mel and OTA failed to induce mitophagy in the liver. Using the GMT approach in which mice were colonised with intestinal microbiota from control-, OTA-, or Mel + OTA-treated mice led us to elucidated the involvement of intestinal microbiota in liver inflammation and mitophagy induced by OTA. The findings suggested that intestinal microbiota play some role in the Mel-induced amelioration of liver inflammation and mitophagy induced by OTA"
Keywords:		Animals Antioxidants *Gastrointestinal Microbiome Inflammation/chemically induced Liver *Melatonin Mice Mitophagy Ochratoxins Oxidative Stress Rats Gut microbiota transplantation Intestinal microbiota Liver mitophagy Melatonin Ochratoxin A;
Notes:		"MedlineZhang, Hao Yan, Ani Liu, Xiaoyun Ma, Yi Zhao, Fangfang Wang, Mengzhi Loor, Jaun J Wang, Hongrong eng Research Support, Non-U.S. Gov't Netherlands 2020/12/29 J Hazard Mater. 2021 Apr 5; 407:124489. doi: 10.1016/j.jhazmat.2020.124489. Epub 2020 Dec 9"