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Food Funct

Title:		N-carbamylglutamate and l-arginine promote intestinal function in suckling lambs with intrauterine growth restriction by regulating antioxidant capacity via a nitric oxide-dependent pathway
Author(s):		Zhang H; Sun H; Peng A; Guo S; Wang M; Loor JJ; Wang H;
Address:		"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, P. R. China. hrwang@yzu.edu.cn"
Journal Title:		Food Funct
Year:		2019
Volume:		10
Issue:		10
Page Number:		6374 - 6384
DOI:		10.1039/c9fo01752f
ISSN/ISBN:		2042-650X (Electronic) 2042-6496 (Linking)
Abstract:		"Data indicate that intrauterine growth restriction (IUGR) in newborns can be partly alleviated through the supply of l-arginine (Arg) and N-carbamylglutamate (NCG). The current work aimed to explore whether Arg and NCG promote intestinal function by regulating antioxidant capacity in suckling lambs with IUGR via a nitric oxide (NO)-dependent pathway. Forty eight newly born Hu lambs with normal weights at birth (CON) or suffering from IUGR were randomly divided into 4 groups (n = 12 per group), namely, the CON, IUGR, IUGR + 1% Arg, and IUGR + 0.1% NCG groups. The animals were used for experiments from the age of day 7 to 28. Compared with the lambs in the IUGR group, the lambs in the Arg or NCG group had higher (P < 0.05) final body weights. The plasma insulin, NO, and NO synthase (NOS) concentrations in the IUGR group were higher (P < 0.05) compared with those in IUGR + 1% Arg or IUGR + 0.1% NCG. The jejunal level of the tumor necrosis factor alpha (TNF-alpha) in the IUGR lambs was greater (P < 0.05) compared with that in IUGR + 1% Arg or IUGR + 0.1% NCG. The plasma and jejunal total antioxidant capacity (T-AOC) values for the IUGR + 1% Arg or IUGR + 0.1% NCG group were greater (P < 0.05) compared with those for the IUGR group. Compared with the IUGR + 1% Arg or IUGR + 0.1% NCG lambs, the IUGR lambs had lower (P < 0.05) abundance of mRNA and protein abundance of glutathione peroxidase 1 (GPx1), catalase (CAT), superoxide dismutase 2 (SOD2), nuclear factor erythroid 2-related factor 2 (Nrf2), quinone oxidoreductase 1 (NQO1), heme oxygenase (HO-1), zonula occludens-1 (ZO-1), occludin, inducible NOS (iNOS), and epithelial NOS (eNOS). Overall, the data suggest that the Arg or NCG supplementation to suckling lambs with IUGR enhances the intestinal function by regulating the oxidant status via the NO-dependent pathway"
Keywords:		Animal Feed/analysis Animals Antioxidants/*metabolism Arginine/*administration & dosage Catalase/genetics/metabolism Dietary Supplements/analysis Female Fetal Growth Retardation/drug therapy/genetics/metabolism/*veterinary Glutamates/*administration & dos;
Notes:		"MedlineZhang, Hao Sun, Hua Peng, Along Guo, Shuang Wang, Mengzhi Loor, Juan J Wang, Hongrong eng England 2019/09/12 Food Funct. 2019 Oct 16; 10(10):6374-6384. doi: 10.1039/c9fo01752f"