| Title: | Lactobacillus for ribosome peptide editing cancer |
| Author(s): | Yue S; He Q; Picimbon JF; |
| Address: | "Biotechnology Research Center, Shandong Academy of Agricultural Sciences, 202 Gongye North Road, Jinan, 250100, Shandong, China. Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Jinan, 250103, Shandong, China. Biotechnology Research Center, Shandong Academy of Agricultural Sciences, 202 Gongye North Road, Jinan, 250100, Shandong, China. jfpicimbon@sdas.org. Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Jinan, 250103, Shandong, China. jfpicimbon@sdas.org. School of Bioengineering, Qilu University of Technology, 3501 University Road, Jinan, 250353, Shandong, China. jfpicimbon@sdas.org" |
| DOI: | 10.1007/s12094-022-03066-5 |
| ISSN/ISBN: | 1699-3055 (Electronic) 1699-048X (Print) 1699-048X (Linking) |
| Abstract: | "This study reviews newly discovered insect peptide point mutations as new possible cancer research targets. To interpret newly discovered peptide point mutations in insects as new possible cancer research targets, we focused on the numerous peptide changes found in the 'CSP' family on the sex pheromone gland of the female silkworm moth Bombyx mori. We predict that the Bombyx peptide modifications will have a significant effect on cancer CUP (cancers of unknown primary) therapy and that bacterial peptide editing techniques, specifically Lactobacillus combined to CRISPR, will be used to regulate ribosomes and treat cancer in humans" |
| Keywords: | Animals Female Humans *Bombyx/genetics Peptides Ribosomes/genetics *Neoplasms/genetics/therapy CSP model Cup Cell multifunction Cell ribosome Cysteine insertion Genetic disease Glycine insertion Malignant tumor Mutational alteration Protein recoding; |
| Notes: | "MedlineYue, Shousong He, Qiuxia Picimbon, Jean-Francois eng NO.tshw20091015/Overseas High-level Talent 'Hundred People Program'/ ZR2011CM046/Natural Science Foundation of Shandong Province/ 2012BAK17B05/National Key Technology Research and Development Program/ 2016GGH3111/Key Technology Research and Development Program of Shandong/ CXGC2017A01-1/Agricultural Science and Technology Innovation Engineering Program of SAAS/ G2022023033L/Ministry of Science and Technology of the People's Republic of China/ Review Italy 2023/01/25 Clin Transl Oncol. 2023 Jun; 25(6):1522-1544. doi: 10.1007/s12094-022-03066-5. Epub 2023 Jan 24" |
