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Curr Genet

Title:		The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans
Author(s):		Yan Z; Hull CM; Sun S; Heitman J; Xu J;
Address:		"Department of Biology, McMaster University, Hamilton, ON, Canada, L8S 4K1"
Journal Title:		Curr Genet
Year:		2007
Volume:		51
Issue:		3
Page Number:		187 - 195
DOI:		10.1007/s00294-006-0115-9
ISSN/ISBN:		0172-8083 (Print) 0172-8083 (Linking)
Abstract:		"In the great majority of sexual eukaryotes, mitochondrial genomes are inherited almost exclusively from a single parent. While many hypotheses have been proposed to explain this phenomenon, very little is known about the genetic elements controlling uniparental mitochondria inheritance. In the bipolar, isogamous basidiomycete yeast Cryptococcus neoformans, progeny from crosses between strains of mating type a (MATa) and mating type alpha (MATalpha) typically inherit mitochondrial DNA (mtDNA) from the MATa parent. We recently demonstrated that a mating type alpha (MATalpha)-specific gene SXI1a, controls mitochondrial inheritance in C. neoformans. Here, we show that another homeodomain gene SXI2a in the alternative mating type MATa is also required for uniparental mtDNA inheritance in this fungus. Disruption of SXI2a resulted in biparental mtDNA inheritance in the zygote population with significant numbers of progeny inheriting mtDNA from the MATa parent, the MATalpha parent, and both the MATa and the MATalpha parents. In addition, progeny from same-sex mating between MATalpha strains showed a biparental mitochondrial inheritance pattern. Our results suggest that SXI1alpha and SXI2a coordinately control uniparental mitochondrial inheritance in C. neoformans"
Keywords:		"Cryptococcus neoformans/*genetics DNA, Mitochondrial/*genetics Extrachromosomal Inheritance/*genetics *Genes, Homeobox *Genes, Mating Type, Fungal Mitochondria/*genetics;"
Notes:		"MedlineYan, Zhun Hull, Christina M Sun, Sheng Heitman, Joseph Xu, Jianping eng Research Support, Non-U.S. Gov't 2006/12/23 Curr Genet. 2007 Mar; 51(3):187-95. doi: 10.1007/s00294-006-0115-9"