| Title: | "Evolution, developmental expression and function of odorant receptors in insects" |
| Author(s): | Yan H; Jafari S; Pask G; Zhou X; Reinberg D; Desplan C; |
| Address: | "Department of Biology, University of Florida, Gainesville, FL 32611, USA. Center for Smell and Taste (UFCST), University of Florida, Gainesville, FL 32610, USA. Department of Molecular Biology, Umea University, 901 87 Umea, Sweden. Department of Biology, New York University, New York, NY 10003, USA. Department of Biology, Bucknell University, Lewisburg, PA 17837, USA. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, 510642 Guangzhou, China. Howard Hughes Medical Institute (HHMI), Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. Department of Biology, New York University, New York, NY 10003, USA cd38@nyu.edu" |
| ISSN/ISBN: | 1477-9145 (Electronic) 0022-0949 (Print) 0022-0949 (Linking) |
| Abstract: | "Animals rely on their chemosensory system to discriminate among a very large number of attractive or repulsive chemical cues in the environment, which is essential to respond with proper action. The olfactory sensory systems in insects share significant similarities with those of vertebrates, although they also exhibit dramatic differences, such as the molecular nature of the odorant receptors (ORs): insect ORs function as heteromeric ion channels with a common Orco subunit, unlike the G-protein-coupled olfactory receptors found in vertebrates. Remarkable progress has recently been made in understanding the evolution, development and function of insect odorant receptor neurons (ORNs). These studies have uncovered the diversity of olfactory sensory systems among insect species, including in eusocial insects that rely extensively on olfactory sensing of pheromones for social communication. However, further studies, notably functional analyses, are needed to improve our understanding of the origins of the Orco-OR system, the mechanisms of ORN fate determination, and the extraordinary diversity of behavioral responses to chemical cues" |
| Keywords: | "Animals Insect Proteins/genetics Insecta/genetics Pheromones *Receptors, Odorant/genetics Smell Ant Development Diversity Drosophila Evolution Odorant Receptor Olfaction Orco;" |
| Notes: | "MedlineYan, Hua Jafari, Shadi Pask, Gregory Zhou, Xiaofan Reinberg, Danny Desplan, Claude eng R01 AG058762/AG/NIA NIH HHS/ R01 EY013010/EY/NEI NIH HHS/ HHMI/Howard Hughes Medical Institute/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England 2020/02/09 J Exp Biol. 2020 Feb 7; 223(Pt Suppl 1):jeb208215. doi: 10.1242/jeb.208215" |
