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FEMS Microbiol Rev

Title:		Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi
Author(s):		Xue C; Hsueh YP; Heitman J;
Address:		"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA"
Journal Title:		FEMS Microbiol Rev
Year:		2008
Volume:		20080922
Issue:		6
Page Number:		1010 - 1032
DOI:		10.1111/j.1574-6976.2008.00131.x
ISSN/ISBN:		0168-6445 (Print) 1574-6976 (Electronic) 0168-6445 (Linking)
Abstract:		"G protein-coupled receptors (GPCRs) represent the largest family of transmembrane receptors and are responsible for transducing extracellular signals into intracellular responses that involve complex intracellular-signaling networks. This review highlights recent research advances in fungal GPCRs, including classification, extracellular sensing, and G protein-signaling regulation. The involvement of GPCRs in pheromone and nutrient sensing has been studied extensively over the past decade. Following recent advances in fungal genome sequencing projects, a panoply of GPCR candidates has been revealed and some have been documented to play key roles sensing diverse extracellular signals, such as pheromones, sugars, amino acids, nitrogen sources, and even photons. Identification and deorphanization of additional putative GPCRs may require the development of new research tools. Here, we compare research on GPCRs in fungi with information derived from mammalian systems to provide a useful road map on how to better understand ligand-GPCR-G protein interactions in general. We also emphasize the utility of yeast as a discovery tool for systemic studies of GPCRs from other organisms"
Keywords:		"Amino Acids/metabolism Animals Extracellular Space/genetics/metabolism Fatty Acids/metabolism Fungal Proteins/*genetics/*metabolism Fungi/genetics/*metabolism Humans Pheromones/metabolism Receptors, G-Protein-Coupled/genetics/*metabolism *Signal Transduct;"
Notes:		"MedlineXue, Chaoyang Hsueh, Yen-Ping Heitman, Joseph eng R21 AI070230-02/AI/NIAID NIH HHS/ R21 AI070230/AI/NIAID NIH HHS/ R01 AI039115/AI/NIAID NIH HHS/ R01 AI039115-10/AI/NIAID NIH HHS/ R01 AI039115-12/AI/NIAID NIH HHS/ R01 AI050113/AI/NIAID NIH HHS/ R01 AI039115-11/AI/NIAID NIH HHS/ R21 AI070230-01A1/AI/NIAID NIH HHS/ Review England 2008/09/25 FEMS Microbiol Rev. 2008 Nov; 32(6):1010-32. doi: 10.1111/j.1574-6976.2008.00131.x. Epub 2008 Sep 22"