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F1000Res

Title:		1-Octen-3-ol - the attractant that repels
Author(s):		Xu P; Zhu F; Buss GK; Leal WS;
Address:		"Department of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA"
Journal Title:		F1000Res
Year:		2015
Volume:		20150618
Issue:
Page Number:		156 -
DOI:		10.12688/f1000research.6646.1
ISSN/ISBN:		2046-1402 (Print) 2046-1402 (Electronic) 2046-1402 (Linking)
Abstract:		"Since the discovery in the early 1980s that 1-octen-3-ol, isolated from oxen breath, attracts tsetse fly, there has been growing interest in exploring the use of this semiochemical as a possible generic lure for trapping host-seeking mosquitoes. Intriguingly, traps baited with 1-octen-3-ol captured significantly more females of the malaria mosquito, Anopheles gambiae, and the yellow fever mosquito, Aedes aegypti, than control traps, but failed to attract the southern house mosquito, Culex quinquefasciatus. Additionally, it has been demonstrated that this attractant is detected with enantioselective odorant receptors (ORs) expressed only in maxillary palps. On the basis of indoor behavioral assays it has even been suggested that 1-octen-3-ol might be a repellent to the southern house mosquito. Our approach was two-prong, i.e., to isolate 1-octen-3-ol-sensitive ORs expressed in maxillary palps and antennae of southern house female mosquito, and test the hypothesis that this semiochemical is a repellent. An OR with high transcript levels in maxillary palps, CquiOR118b, showed remarkable selectivity towards ( R)-1-octen-3-ol, whereas an OR expressed in antennae, CquiOR114b, showed higher preference for ( S)-1-octen-3-ol than its antipode. Repellency by a surface landing and feeding assay showed that not only racemic, but enantiopure ( R)- and ( S)-1-octen-3-ol are repellents at 1% dose thus suggesting the occurrence of other ( S)-1-octen-3-ol-sensitive OR(s). Female mosquitoes with ablated maxillary palps were repelled by 1-octen-3-ol, which implies that in addition to OR(s) in the maxillary palps, antennal OR(s) are essential for repellency activity"
Keywords:		CquiOR114b CquiOR118b Culex quinquefasciatus antennae chiral discrimination maxillary palps odorant receptors repellency assay;
Notes:		"PubMed-not-MEDLINEXu, Pingxi Zhu, Fen Buss, Garrison K Leal, Walter S eng R01 AI095514/AI/NIAID NIH HHS/ England 2015/11/07 F1000Res. 2015 Jun 18; 4:156. doi: 10.12688/f1000research.6646.1. eCollection 2015"