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ACS Omega

Title:		Amine-Functionalized ZIF-8 as a Fluorescent Probe for Breath Volatile Organic Compound Biomarker Detection of Lung Cancer Patients
Author(s):		Xia Y; Hong Y; Geng R; Li X; Qu A; Zhou Z; Zhang Z;
Address:		"Institute of Mass Spectrometer and Atmospheric Environment, Jinan University, Guangzhou 510632, China. Guangdong Provincial Engineering Research Center for Online Source Apportionment System of Air Pollution, Guangzhou 510632, China. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China. College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China"
Journal Title:		ACS Omega
Year:		2020
Volume:		20200213
Issue:		7
Page Number:		3478 - 3486
DOI:		10.1021/acsomega.9b03793
ISSN/ISBN:		2470-1343 (Electronic) 2470-1343 (Linking)
Abstract:		"The highly thermally and chemically stable imidazole framework ZIF-8 samples were separately postmodified with amine groups by using N,N'-dimethylethylenediamine (MMEN) and N,N-dimethylaminoethylamine (MAEA), which had the same molecular formula but different structures. The modified ZIF-8 samples (ZIF-8@amine) were thoroughly characterized, including powder X-ray diffractometry, Fourier-transformed infrared spectroscopy, and physical adsorption at 77 K by nitrogen, thermogravimetric analysis, and photophysical characterization. Results showed that after modification, the Brunauer-Emmett-Teller surface area and total pore volume both increased, almost one time higher than those of the original ZIF-8 sample, and followed the order: ZIF-8-MMEN > ZIF-8-MAEA > ZIF-8. Furthermore, the N-H group was successfully grafted into the modified ZIF-8 samples. To examine the sensing properties of the modified ZIF-8@amine samples toward the breath biomarkers of lung cancer, five potential volatile organic compound biomarkers were used as analytes. ZIF-8-MMEN and ZIF-8-MAEA revealed a unique capacity for sensing hexanal, ethylbenzene, and 1-propanol with high efficiency and sensitivity. The three samples all did not show sensing ability toward styrene and isoprene. In addition, ZIF-8, ZIF-8-MMEN, and ZIF-8-MAEA all can sense hexanal with a detection limit as low as 1 ppb"
Keywords:
Notes:		"PubMed-not-MEDLINEXia, Yuanhan Hong, Yi Geng, Rongchuang Li, Xue Qu, Ailan Zhou, Zhen Zhang, Zhijuan eng 2020/03/03 ACS Omega. 2020 Feb 13; 5(7):3478-3486. doi: 10.1021/acsomega.9b03793. eCollection 2020 Feb 25"