| Title: | Genomic and experimental evidence for a potential sexual cycle in the pathogenic thermal dimorphic fungus Penicillium marneffei |
| Author(s): | Woo PC; Chong KT; Tse H; Cai JJ; Lau CC; Zhou AC; Lau SK; Yuen KY; |
| Address: | "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong" |
| DOI: | 10.1016/j.febslet.2006.05.014 |
| ISSN/ISBN: | 0014-5793 (Print) 0014-5793 (Linking) |
| Abstract: | "All meiotic genes (except HOP1) and genes encoding putative pheromone processing enzymes, pheromone receptors and pheromone response pathways proteins in Aspergillus fumigatus and Aspergillus nidulans and a putative MAT-1 alpha box mating-type gene were present in the Penicillium marneffei genome. A putative MAT-2 high-mobility group mating-type gene was amplified from a MAT-1 alpha box mating-type gene-negative P. marneffei strain. Among 37 P. marneffei patient strains, MAT-1 alpha box and MAT-2 high-mobility group mating-type genes were present in 23 and 14 isolates, respectively. We speculate that P. marneffei can potentially be a heterothallic fungus that does not switch mating type" |
| Keywords: | "Amino Acid Sequence Base Sequence DNA Primers *Genome, Fungal Mating Factor Molecular Sequence Data Penicillium/classification/*genetics/*physiology Peptides/chemistry/genetics Phylogeny Polymerase Chain Reaction Sequence Homology, Amino Acid;" |
| Notes: | "MedlineWoo, Patrick C Y Chong, Ken T K Tse, Herman Cai, James J Lau, Candy C Y Zhou, Anna C Lau, Susanna K P Yuen, Kwok-yung eng Research Support, Non-U.S. Gov't England 2006/05/23 FEBS Lett. 2006 Jun 12; 580(14):3409-16. doi: 10.1016/j.febslet.2006.05.014. Epub 2006 May 11" |
