« Previous AbstractEnvironmental isolation of Cryptococcus gattii VGII from indoor dust from typical wooden houses in the deep Amazonas of the Rio Negro basin    Next Abstract"Antimicrobial, antioxidant, volatile and phenolic profiles of cabbage-stalk and pineapple-crown flour revealed by GC-MS and UPLC-MS(E)" »

Toxicol Sci

Title:		Acute cardiovascular and inflammatory toxicity induced by inhalation of diesel and biodiesel exhaust particles
Author(s):		Brito JM; Belotti L; Toledo AC; Antonangelo L; Silva FS; Alvim DS; Andre PA; Saldiva PH; Rivero DH;
Address:		"Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil"
Journal Title:		Toxicol Sci
Year:		2010
Volume:		20100412
Issue:		1
Page Number:		67 - 78
DOI:		10.1093/toxsci/kfq107
ISSN/ISBN:		1096-0929 (Electronic) 1096-0929 (Linking)
Abstract:		"Analysis of fuel emissions is crucial for understanding the pathogenesis of mortality because of air pollution. The objective of this study is to assess cardiovascular and inflammatory toxicity of diesel and biodiesel particles. Mice were exposed to fuels for 1 h. Heart rate (HR), heart rate variability, and blood pressure were obtained before exposure, as well as 30 and 60 min after exposure. After 24 h, bronchoalveolar lavage, blood, and bone marrow were collected to evaluate inflammation. B100 decreased the following emission parameters: mass, black carbon, metals, CO, polycyclic aromatic hydrocarbons, and volatile organic compounds compared with B50 and diesel; root mean square of successive differences in the heart beat interval increased with diesel (p < 0.05) compared with control; low frequency increased with diesel (p < 0.01) and B100 (p < 0.05) compared with control; HR increased with B100 (p < 0.05) compared with control; mean corpuscular volume increased with B100 compared with diesel (p < 0.01), B50, and control (p < 0.001); mean corpuscular hemoglobin concentration decreased with B100 compared with B50 (p < 0.001) and control (p < 0.05); leucocytes increased with B50 compared with diesel (p < 0.05); platelets increased with B100 compared with diesel and control (p < 0.05); reticulocytes increased with B50 compared with diesel, control (p < 0.01), and B100 (p < 0.05); metamyelocytes increased with B50 and B100 compared with diesel (p < 0.05); neutrophils increased with diesel and B50 compared with control (p < 0.05); and macrophages increased with diesel (p < 0.01), B50, and B100 (p < 0.05) compared with control. Biodiesel was more toxic than diesel because it promoted cardiovascular alterations as well as pulmonary and systemic inflammation"
Keywords:		"Animals Bronchoalveolar Lavage Fluid Cardiovascular Diseases/*chemically induced Inflammation/*chemically induced Inhalation Exposure Mice Mice, Inbred BALB C *Vehicle Emissions;"
Notes:		"MedlineBrito, Jose Mara Belotti, Luciano Toledo, Alessandra C Antonangelo, Leila Silva, Flavio S Alvim, Debora S Andre, Paulo A Saldiva, Paulo H N Rivero, Dolores H R F eng Research Support, Non-U.S. Gov't 2010/04/14 Toxicol Sci. 2010 Jul; 116(1):67-78. doi: 10.1093/toxsci/kfq107. Epub 2010 Apr 12"