| Title: | Intrauterine position affects sex-accessory biochemistry in adult female mice |
| Author(s): | Wechman R; Brown M; Hilton F; |
| DOI: | 10.1095/biolreprod33.4.803 |
| ISSN/ISBN: | 0006-3363 (Print) 0006-3363 (Linking) |
| Abstract: | "Female mouse fetuses that develop in utero implanted between two male fetuses (2M females) are shown as adults to have significantly elevated (P less than 0.01) levels of beta-glucuronidase activity in their preputial glands compared to that of OM females, females that had not been contiguous to males in utero, and 1M females, females contiguous in utero to only one male (mean +/- SEM, 2M females = 23,9 +/- 2.1, 1M females = 13.3 +/- 5.2, and OM females = 7.8 +/- 2.5 Modified Sigma Units/mg frozen weight). It is hypothesized that the increased enzymatic activity in the preputial glands of 2M females could be important in releasing steroid metabolites from voided urine. These metabolites could then act as pheromones and thus explain some of the described differences in sexual behavior correlated with intrauterine position" |
| Keywords: | Animals Female Fetus/*physiology Glucuronidase/*metabolism Male Mice Orchiectomy Penis/enzymology Pregnancy Sebaceous Glands/drug effects/*enzymology Seminal Vesicles/drug effects/*enzymology Sex Factors Testosterone/pharmacology Uterus/*physiology; |
| Notes: | "MedlineWechman, R Jr Brown, M Hilton, F eng Research Support, Non-U.S. Gov't 1985/11/01 Biol Reprod. 1985 Nov; 33(4):803-7. doi: 10.1095/biolreprod33.4.803" |
