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Front Microbiol

Title:		The Critical Role of Potassium Efflux and Nek7 in Pasteurella multocida-Induced NLRP3 Inflammasome Activation
Author(s):		Wang Y; Zeng Z; Ran J; Peng L; Wu X; Ye C; Dong C; Peng Y; Fang R;
Address:		"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, China. Chongqing Animal Disease Prevention and Control Center, Chongqing, China. Immunology Research Center, Medical Research Institute, Southwest University, Chongqing, China. Chongqing Key Laboratory of Herbivore Science, Chongqing, China"
Journal Title:		Front Microbiol
Year:		2022
Volume:		20220308
Issue:
Page Number:		849482 -
DOI:		10.3389/fmicb.2022.849482
ISSN/ISBN:		1664-302X (Print) 1664-302X (Electronic) 1664-302X (Linking)
Abstract:		"Pasteurella multocida is a zoonotic pathogen causing respiratory infection in different animal species such as cattle, sheep, pigs, chickens and humans. Inflammasome is a complex assembled by multiple proteins in the cytoplasm and plays an important role in the host defense against microbial infection. Bovine Pasteurella multocida type A (PmCQ2) infection induces NLRP3 inflammasome activation and IL-1beta secretion, but the mechanism of PmCQ2-induced activation of NLRP3 inflammasome is still unknown. Therefore, the underlying mechanism was investigated in this study. The results showed that potassium efflux mediated PmCQ2-induced IL-1beta secretion and blocking potassium efflux attenuated PmCQ2-induced caspase-1 activation and ASC oligomerization. Furthermore, NIMA-related kinase 7 (Nek7) was also involved in PmCQ2-induced caspase-1 activation and IL-1beta secretion. In addition, PmCQ2 infection promoted Nek7-NLRP3 interaction, which is dependent on potassium efflux. In conclusion, our results indicate the critical role of potassium efflux and Nek7 in Pasteurella multocida-induced NLRP3 inflammasome activation, which provides useful information about Pasteurella multocida-induced host immune response"
Keywords:		NLRP3 inflammasome Nek7 Pasteurella multocida immunity potassium efflux;
Notes:		"PubMed-not-MEDLINEWang, Yu Zeng, Zheng Ran, Jinrong Peng, Lianci Wu, Xingping Ye, Chao Dong, Chunxia Peng, Yuanyi Fang, Rendong eng Switzerland 2022/03/31 Front Microbiol. 2022 Mar 8; 13:849482. doi: 10.3389/fmicb.2022.849482. eCollection 2022"