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Biotechnol Prog

Title:		Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa
Author(s):		Viretta AU; Fussenegger M;
Address:		"Institute of Biotechnology, ETH Hoenggerberg HPT D74, CH-8093 Zurich, Switzerland"
Journal Title:		Biotechnol Prog
Year:		2004
Volume:		20
Issue:		3
Page Number:		670 - 678
DOI:		10.1021/bp034323l
ISSN/ISBN:		8756-7938 (Print) 1520-6033 (Linking)
Abstract:		"The biochemical network underlying quorum sensing in human-pathogenic Pseudomonas aeruginosa is one of the best characterized. Mathematical modeling is required to untangle the complexity of its architecture and dynamics. We present a qualitative model of the P. aeruginosa quorum-sensing network including interactions between the las and rhl modules, the signaling molecule PQS and the regulatory proteins Mvfr and VfR. Simulations exemplify the model to reproduce natural network behavior and suggest quorum-sensing responses to pharmacological interference"
Keywords:		"4-Butyrolactone/*analogs & derivatives/metabolism Bacterial Proteins/*metabolism Computer Simulation DNA-Binding Proteins/metabolism Gene Expression Regulation, Bacterial/*physiology Homoserine/*analogs & derivatives/metabolism Humans *Models, Biological;"
Notes:		"MedlineViretta, Alessandro Usseglio Fussenegger, Martin eng Comparative Study Evaluation Study Research Support, Non-U.S. Gov't Validation Study 2004/06/05 Biotechnol Prog. 2004 May-Jun; 20(3):670-8. doi: 10.1021/bp034323l"