| Title: | Hidden agenda of Enterococcus faecalis lifestyle transition: planktonic to sessile state |
| Author(s): | Venkateswaran P; Lakshmanan PM; Muthukrishnan S; Bhagavathi H; Vasudevan S; Neelakantan P; Solomon AP; |
| Address: | "Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical & Biotechnology, SASTRA Deemed to be University, Thanjavur, 613401, India. Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong" |
| ISSN/ISBN: | 1746-0921 (Electronic) 1746-0913 (Linking) |
| Abstract: | "Enterococcus faecalis, a human gastrointestinal tract commensal, is known to cause nosocomial infections. Interestingly, the pathogen's host colonization and persistent infections are possibly linked to its lifestyle changes from planktonic to sessile state. Also, the multidrug resistance and survival fitness acquired in the sessile stage of E. faecalis has challenged treatment regimes. This situation exists because of the critical role played by several root genes and their molecular branches, which are part of quorum sensing, aggregation substance, surface adhesions, stress-related response and sex pheromones in the sessile state. It is therefore imperative to decode the hidden agenda of E. faecalis and understand the significant factors influencing biofilm formation. This would, in turn, augment the development of novel strategies to tackle E. faecalis infections" |
| Keywords: | Biofilms *Enterococcus faecalis/genetics Humans Life Style *Plankton Quorum Sensing/physiology Enterococcus faecalis biofilm nosocomial pathogen planktonic virulence; |
| Notes: | "MedlineVenkateswaran, Parvathy Lakshmanan, Priya M Muthukrishnan, Sudhiksha Bhagavathi, Hema Vasudevan, Sahana Neelakantan, Prasanna Solomon, Adline P eng Review England 2022/07/29 Future Microbiol. 2022 Sep; 17:1051-1069. doi: 10.2217/fmb-2021-0212. Epub 2022 Jul 28" |
