« Previous AbstractDecoding the proteomic changes involved in the biofilm formation of Enterococcus faecalis SK460 to elucidate potential biofilm determinants    Next Abstract"Interspecific Mating Effect of Bactrocera carambolae and Bactrocera dorsalis on its Fecundity, Survival and Morphologies" »

Future Microbiol

Title:		Comprehensive genomics depict accessory genes encoding pathogenicity and biofilm determinants in Enterococcus faecalis
Author(s):		Suryaletha K; Chandrika SK; Thomas S;
Address:		"Cholera & Biofilm Research Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695 014, Kerala, India. Distributed Information Sub-Centre, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695 014, Kerala, India"
Journal Title:		Future Microbiol
Year:		2021
Volume:		20210202
Issue:		3
Page Number:		175 - 184
DOI:		10.2217/fmb-2020-0111
ISSN/ISBN:		1746-0921 (Electronic) 1746-0913 (Linking)
Abstract:		"Aim:Enterococcus faecalis is a leading nosocomial pathogen in biofilm-associated polymicrobial infections. The study aims to understand pathogenicity and biofilm determinants of the pathogen by genome analysis. Methodology: Genome sequencing of a strong biofilm forming clinical isolate Enterococcus faecalis SK460 devoid of Fsr quorum-signaling system, was performed and comparative genomics was carried out among a set of pathogenic biofilm formers and nonpathogenic weak biofilm formers. Results: Analysis revealed a pool of virulence and adhesion related factors associated with pathogenicity. Absence of CRISPR-Cas system facilitated acquisition of pheromone responsive plasmid, pathogenicity island and phages. Comprehensive analysis identified a subset of accessory genes encoding polysaccharide lyase, sugar phosphotransferase system, phage proteins and transcriptional regulators exclusively in pathogenic biofilm formers. Conclusion: The study identified a set of genes specific to pathogenic biofilm formers and these can act as targets which in turn help to develop future treatment endeavors against enterococcal infections"
Keywords:		"Bacterial Proteins/*genetics/metabolism *Biofilms CRISPR-Cas Systems Enterococcus faecalis/*genetics/*pathogenicity/physiology Genome, Bacterial Genomic Islands Gram-Positive Bacterial Infections/microbiology Humans Plasmids/genetics/metabolism Virulence;"
Notes:		"MedlineSuryaletha, Karthika Chandrika, Sivakumar K Thomas, Sabu eng Research Support, Non-U.S. Gov't England 2021/02/03 Future Microbiol. 2021 Feb; 16(3):175-184. doi: 10.2217/fmb-2020-0111. Epub 2021 Feb 2"