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FEMS Microbiol Lett

Title:		Induction of phenazine biosynthesis in cultures of Pseudomonas aeruginosa by L-N-(3-oxohexanoyl)homoserine lactone
Author(s):		Stead P; Rudd BA; Bradshaw H; Noble D; Dawson MJ;
Address:		"Natural Products Chemistry Section, Glaxo Wellcome Medicines Research Centre, Stevenage, Herts, UK"
Journal Title:		FEMS Microbiol Lett
Year:		1996
Volume:		140
Issue:		1
Page Number:		15 - 22
DOI:		10.1111/j.1574-6968.1996.tb08308.x
ISSN/ISBN:		0378-1097 (Print) 0378-1097 (Linking)
Abstract:		"A range of Pseudomonas spp. and other Gram-negative bacteria were screened for induction of antimicrobial activity in response to the autoregulatory factor L-N-(3-oxohexanoyl)homoserine lactone. In one of these, P. aeruginosa ATCC 10145, the production of phenazine metabolites was shown to be inducible in a dose-dependent manner. The production of phenazine-1-carboxamide increased over 50-fold compared to control cultures when supplemented with 200 micrograms/ml of the autoregulator. In addition, the production of an unidentified polar antibacterial substance by this strain increased with autoregulator concentration"
Keywords:		"4-Butyrolactone/*analogs & derivatives/pharmacology Bacillus subtilis/drug effects/metabolism Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Escherichia coli/drug effects/metabolism Gram-Negative Bacteria/drug effects/metabolism Mic;"
Notes:		"MedlineStead, P Rudd, B A Bradshaw, H Noble, D Dawson, M J eng England 1996/06/15 FEMS Microbiol Lett. 1996 Jun 15; 140(1):15-22. doi: 10.1111/j.1574-6968.1996.tb08308.x"