| Title: | High sensitivity for lung cancer detection using analysis of exhaled carbonyl compounds |
| Author(s): | Schumer EM; Trivedi JR; van Berkel V; Black MC; Li M; Fu XA; Bousamra M; |
| Address: | "Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine, Louisville, Ky. Department of Chemical Engineering, University of Louisville School of Medicine, Louisville, Ky. Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine, Louisville, Ky. Electronic address: michael.bousamra@louisville.edu" |
| DOI: | 10.1016/j.jtcvs.2015.08.092 |
| ISSN/ISBN: | 1097-685X (Electronic) 0022-5223 (Linking) |
| Abstract: | "OBJECTIVE: Several volatile carbonyl compounds in exhaled breath have been identified as cancer-specific markers. The potential for these markers to serve as a screening test for lung cancer is reported. METHODS: Patients with computed tomography-detected intrathoracic lesions and healthy control participants were enrolled from 2011 onward. One liter of breath was collected from a single exhalation from each participant. The contents were evacuated over a silicon microchip, captured by oximation reaction, and analyzed by mass spectrometry. Concentrations of 2-butanone, 3-hydroxy-2-butanone, 2-hydroxyacetaldehyde, and 4-hydroxyhexanal were measured. The overall population was divided into 3 groups: those with lung cancer, benign disease, and healthy controls. An elevated cancer marker was defined as >/=1.5 SDs above the mean concentration of the control population. One or more elevated cancer markers constituted a positive breath test. RESULTS: In all, 156 subjects had lung cancer, 65 had benign disease, and 194 were healthy controls. A total of 103 (66.0%) lung cancer patients were early stage (stage 0, I, and II). For >/=1 elevated cancer marker, breath analysis showed a sensitivity of 93.6%, and a specificity of 85.6% for lung cancer patients. Additionally, 83.7% of stage I tumors |
| Keywords: | "Acetaldehyde/analogs & derivatives/analysis Acetoin/analysis Aged Aldehydes/analysis Biomarkers, Tumor/analysis Breath Tests Butanones/analysis Case-Control Studies Female Humans Lung Neoplasms/*diagnosis Male Mass Screening/*methods Mass Spectrometry Mid;" |
| Notes: | "MedlineSchumer, Erin M Trivedi, Jaimin R van Berkel, Victor Black, Matthew C Li, Mingxiao Fu, Xiao-An Bousamra, Michael 2nd eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2015/09/29 J Thorac Cardiovasc Surg. 2015 Dec; 150(6):1517-22; discussion 1522-4. doi: 10.1016/j.jtcvs.2015.08.092. Epub 2015 Aug 31" |
