« Previous AbstractEvidence for GABA-Induced Systemic GABA Accumulation in Arabidopsis upon Wounding    Next AbstractField evidence of an airborne enemy-avoidance kairomone in wolf spiders »

Clin Nephrol

Title:		Exhaled breath volatile organic and inorganic compound composition in end-stage renal disease
Author(s):		Schonermarck U; Dengler C; Gmeinwieser A; Praun S; Schelling G; Fischereder M; Boulesteix AL; Dolch ME;
Address:
Journal Title:		Clin Nephrol
Year:		2016
Volume:		86
Issue:		9
Page Number:		132 - 140
DOI:		10.5414/CN108614
ISSN/ISBN:		0301-0430 (Print) 0301-0430 (Linking)
Abstract:		"AIMS: Patients with end-stage renal disease (ESRD) are characterized by uremia and increased oxidative stress. The aim of this study was to investigate the influence of hemodialysis on breath ammonia and volatile oxidative stress parameters. METHODS: Breath analysis was performed in 18 ESRD patients prior, during, and 30 minutes after a hemodialysis session. Parameters of hemodialysis efficiency and oxidative stress (lipid peroxides, total antioxidative capacity, myeloperoxidase, and malondialdehyde) were measured in blood at the beginning, after 30 minutes, and at the end of the dialysis session. 11 healthy volunteers with normal renal function served as a control group. Ion-molecule reaction mass spectrometry was used for breath-gas analysis. RESULTS: Initial elevated concentrations of breath ammonia decreased during hemodialysis and correlated with serum urea levels (r2 = 0.74), whereas isoprene concentrations increased. Breath concentrations of malondialdehyde and pentane (MDA-P) were significantly elevated in ESRD patients (p < 0.01). Within the blood, a significant decrease of malondialdehyde was notable during hemodialysis treatment, whereas levels of lipid peroxides and myeloperoxidase increased. CONCLUSION: Exhaled breath of patients with ESRD on regular hemodialysis treatment is characterized by an increase in ammonia and MDA-P. The efficient decrease of breath ammonia and its close correlation to serum urea during hemodialysis suggests its possible use as a noninvasive marker to monitor dialysis efficacy"
Keywords:		"Adult Biomarkers/analysis Breath Tests *Exhalation Female Humans Kidney Failure, Chronic/diagnosis/metabolism/*therapy Male Middle Aged Renal Dialysis/*adverse effects/*methods Volatile Organic Compounds/*analysis;"
Notes:		"MedlineSchonermarck, Ulf Dengler, Christina Gmeinwieser, Annegret Praun, Siegfried Schelling, Gustav Fischereder, Michael Boulesteix, Anne-Laure Dolch, Michael E eng Germany 2016/07/23 Clin Nephrol. 2016 Sep; 86(9):132-40. doi: 10.5414/CN108614"