| Title: | Goalpha expression in the vomeronasal organ and olfactory bulb of the tammar wallaby |
| Author(s): | Schneider NY; Fletcher TP; Shaw G; Renfree MB; |
| Address: | "The Australian Research Council Centre of Excellence in Kangaroo Genomics, Department of Zoology, The University of Melbourne, Victoria 3010, Australia. nanette@finistere-virtuell.de" |
| ISSN/ISBN: | 1464-3553 (Electronic) 0379-864X (Linking) |
| Abstract: | "The vomeronasal organ (VNO) detects pheromones via 2 large families of receptors: vomeronasal receptor 1, associated with the protein Gialpha2, and vomeronasal receptor 2, associated with Goalpha. We investigated the distribution of Goalpha in the developing and adult VNO and adult olfactory bulb of a marsupial, the tammar wallaby. Some cells expressed Goalpha as early as day 5 postpartum, but by day 30, Goalpha expressing cells were distributed throughout the receptor epithelium of the VNO. In the adult tammar, Goalpha appeared to be expressed in sensory neurons whose nuclei were mostly basally located in the vomeronasal receptor epithelium. Goalpha expressing vomeronasal receptor cells led to all areas of the accessory olfactory bulb (AOB). The lack of regionally restricted projection of the vomeronasal receptor cell type 2 in the tammar was similar to the uniform type, with the crucial difference that the uniform type only shows expression of Gialpha2 and no expression of Goalpha. The observed Goalpha staining pattern suggests that the tammar may have a third accessory olfactory type that could be intermediate to the segregated and uniform types already described" |
| Keywords: | "Animals Female GTP-Binding Protein alpha Subunits, Gi-Go/analysis/*biosynthesis Macropodidae/*metabolism Male Mice Olfactory Bulb/*metabolism Vomeronasal Organ/*metabolism;" |
| Notes: | "MedlineSchneider, Nanette Y Fletcher, Terrence P Shaw, Geoff Renfree, Marilyn B eng Research Support, Non-U.S. Gov't England 2012/03/03 Chem Senses. 2012 Jul; 37(6):567-77. doi: 10.1093/chemse/bjs040. Epub 2012 Mar 1" |
