« Previous AbstractA novel class of peptide pheromone precursors in ascomycetous fungi    Next AbstractAnalysis of volatile organic compounds in exhaled breath to diagnose ventilator-associated pneumonia »

Fungal Biol

Title:		"Light, stress, sex and carbon - The photoreceptor ENVOY as a central checkpoint in the physiology of Trichoderma reesei"
Author(s):		Schmoll M;
Address:		"AIT Austrian Institute of Technology, Department of Health and Environment, Bioresources, Konrad Lorenz Strasse 24, 3430 Tulln, Austria. Electronic address: monika.schmoll@ait.ac.at"
Journal Title:		Fungal Biol
Year:		2018
Volume:		20171026
Issue:		6
Page Number:		479 - 486
DOI:		10.1016/j.funbio.2017.10.007
ISSN/ISBN:		1878-6146 (Print)
Abstract:		"Trichoderma reesei represents one of the most prolific producers of homologous and heterologous proteins. Discovery of the photoreceptor ENV1 as a regulator of cellulase gene expression initiated analysis of light response pathways and their physiological relevance for T. reesei. The function of ENV1 in regulation of plant cell wall degrading enzymes is conserved in Neurospora crassa. ENV1 emerged as a central checkpoint for integration of nutrient sensing, light response and development. This photoreceptor exerts its function by influencing transcript abundance and feedback cycles of the alpha subunits of the heterotrimeric G-protein pathway and impacts regulation of the beta and gamma subunits via mutual regulation with the phosducin PhLP1. The output of regulation by ENV1 is in part mediated by the cAMP pathway and likely aimed at cellulose recognition. Lack of ENV1 causes deregulation of the pheromone system and female sterility in light. A regulatory interconnection with VEL1 and influence on other regulators of secondary metabolism like YPR2 as well as polyketide synthase encoding genes indicates a function in secondary metabolism. The function of ENV1 in integrating light response with signaling of osmotic and oxidative stress is evolutionary conserved in Hypocreales and distinct from other sordariomycetes including N. crassa"
Keywords:		"Eye Proteins/metabolism Fungal Proteins/genetics/*metabolism GTP-Binding Protein Regulators/metabolism Gene Expression Regulation, Fungal Heterotrimeric GTP-Binding Proteins/genetics Pheromones/metabolism Phosphoproteins/metabolism Photoreceptors, Microbi;"
Notes:		"MedlineSchmoll, Monika eng Research Support, Non-U.S. Gov't Netherlands 2018/05/29 Fungal Biol. 2018 Jun; 122(6):479-486. doi: 10.1016/j.funbio.2017.10.007. Epub 2017 Oct 26"