| Title: | Deciphering the genome and secondary metabolome of the plant pathogen Fusarium culmorum |
| Author(s): | Schmidt R; Durling MB; de Jager V; Menezes RC; Nordkvist E; Svatos A; Dubey M; Lauterbach L; Dickschat JS; Karlsson M; Garbeva P; |
| Address: | "Department of Microbial Ecology, Netherlands Institute of Ecology, Droevendaalsesteeg 10,6708 PB Wageningen, the Netherlands. Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Box 7026, 75007 Uppsala, Sweden. Max Planck Institute for Chemical Ecology, D-07745 Jena, Germany. National Veterinary Institute, SE-75189 Uppsala, Sweden. Kekule-Institute of Organic Chemistry and Biochemistry, University of Bonn, D-53121 Bonn, Germany" |
| ISSN/ISBN: | 1574-6941 (Electronic) 0168-6496 (Linking) |
| Abstract: | "Fusarium culmorum is one of the most important fungal plant pathogens that causes diseases on a wide diversity of cereal and non-cereal crops. We report herein for the first time the genome sequence of F. culmorum strain PV and its associated secondary metabolome that plays a role in the interaction with other microorganisms and contributes to its pathogenicity on plants. The genome revealed the presence of two terpene synthases, trichodiene and longiborneol synthase, which generate an array of volatile terpenes. Furthermore, we identified two gene clusters, deoxynivalenol and zearalenone, which encode for the production of mycotoxins. Linking the production of mycotoxins with in vitro bioassays, we found high virulence of F. culmorum PV on maize, barley and wheat. By using ultra-performance liquid chromatography-mass spectrometry, we confirmed several compounds important for the behaviour and lifestyle of F. culmorum. This research sets the basis for future studies in microbe-plant interactions" |
| Keywords: | "Alkyl and Aryl Transferases/*genetics Cyclohexenes/metabolism Edible Grain/microbiology Fusarium/*genetics/*metabolism Genome, Fungal/*genetics Geologic Sediments/microbiology Hordeum/microbiology Metabolome/*physiology Mycotoxins/biosynthesis Plant Disea;" |
| Notes: | "MedlineSchmidt, Ruth Durling, Mikael B de Jager, Victor Menezes, Riya C Nordkvist, Erik Svatos, Ales Dubey, Mukesh Lauterbach, Lukas Dickschat, Jeroen S Karlsson, Magnus Garbeva, Paolina eng Research Support, Non-U.S. Gov't England 2018/05/03 FEMS Microbiol Ecol. 2018 Jun 1; 94(6). doi: 10.1093/femsec/fiy078" |
