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FEMS Microbiol Lett

Title:		Human TSG101 does not replace Saccharomyces cerevisiae VPS23 role in the quality control of plasma membrane proteins
Author(s):		Blanco S; Lazo PA;
Address:		"Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas - Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain"
Journal Title:		FEMS Microbiol Lett
Year:		2003
Volume:		221
Issue:		2
Page Number:		151 - 154
DOI:		10.1016/S0378-1097(03)00179-4
ISSN/ISBN:		0378-1097 (Print) 0378-1097 (Linking)
Abstract:		"The Saccharomyces cerevisiae VPS23 (STP22) gene is implicated in the control of vesicle movement and quality of plasma membrane proteins. VPS23 mutants have defects either in removing defective membrane proteins such as alpha-mating factor receptor and arginine permease. The human ortholog TSG101 and its variants, isolated from tumor cells, do not substitute VPS23 in its ability to rescue the phenotype of defective plasma membrane proteins"
Keywords:		Arginine Carrier Proteins/genetics/*metabolism Cell Membrane/*metabolism DNA-Binding Proteins/genetics/*metabolism Endosomal Sorting Complexes Required for Transport Gene Expression Genetic Complementation Test Humans Mating Factor Membrane Proteins/genet;
Notes:		"MedlineBlanco, Sandra Lazo, Pedro A eng Research Support, Non-U.S. Gov't England 2003/05/03 FEMS Microbiol Lett. 2003 Apr 25; 221(2):151-4. doi: 10.1016/S0378-1097(03)00179-4"