| Title: | MicroRNA expression is associated with auditory dysfunction in workers exposed to ototoxic solvents and noise |
| Author(s): | Sisto R; Moleti A; Capone P; Sanjust F; Cerini L; Tranfo G; Massini G; Buscema S; Buscema PM; Chiarella P; |
| Address: | "Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers Compensation Authority (INAIL), Rome, Italy. Department of Physics and NAST Centre, University of Roma Tor Vergata, Rome, Italy. Semeion, Research Center of Sciences of Communication, Rome, Italy" |
| DOI: | 10.3389/fpubh.2022.958181 |
| ISSN/ISBN: | 2296-2565 (Electronic) 2296-2565 (Linking) |
| Abstract: | "This study is part of a project on early hearing dysfunction induced by combined exposure to volatile organic compounds (VOCs) and noise in occupational settings. In a previous study, 56 microRNAs were found differentially expressed in exposed workers compared to controls. Here, we analyze the statistical association of microRNA expression with audiometric hearing level (HL) and distortion product otoacoustic emission (DPOAE) level in that subset of differentially expressed microRNAs. The highest negative correlations were found; for HL, with miR-195-5p and miR-122-5p, and, for DPOAEs, with miR-92b-5p and miR-206. The homozygous (mut) and heterozygous (het) variants of the gene hOGG1 were found disadvantaged with respect to the wild-type (wt), as regards the risk of hearing impairment due to exposure to VOCs. An unsupervised artificial neural network (auto contractive map) was also used to detect and show, using graph analysis, the hidden connections between the explored variables. These findings may contribute to the formulation of mechanistic hypotheses about hearing damage due to co-exposure to noise and ototoxic solvents" |
| Keywords: | "Auditory Threshold *Hearing Loss, Noise-Induced/diagnosis/genetics Humans *MicroRNAs/genetics *Ototoxicity Solvents/toxicity *Volatile Organic Compounds/adverse effects artificial neural networks auditory function auto contractive map hearing level microR;" |
| Notes: | "MedlineSisto, Renata Moleti, Arturo Capone, Pasquale Sanjust, Filippo Cerini, Luigi Tranfo, Giovanna Massini, Giulia Buscema, Sara Buscema, Paolo Massimo Chiarella, Pieranna eng Research Support, Non-U.S. Gov't Switzerland 2022/10/08 Front Public Health. 2022 Sep 20; 10:958181. doi: 10.3389/fpubh.2022.958181. eCollection 2022" |
