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Front Mol Biosci

Title:		Gene Duplications in the Genomes of Staphylococci and Enterococci
Author(s):		Sanchez-Herrero JF; Bernabeu M; Prieto A; Huttener M; Juarez A;
Address:		"Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain. Biodiversity Research Institute (IRBio), University of Barcelona, Barcelona, Spain. High Content Genomics and Bioinformatics Unit, Germans Trias i Pujol Research Institute (IGTP), Campus Can Ruti, Badalona, Spain. Institute for Bioengineering of Catalonia, The Barcelona Institute of Science and Technology, Barcelona, Spain"
Journal Title:		Front Mol Biosci
Year:		2020
Volume:		20200723
Issue:
Page Number:		160 -
DOI:		10.3389/fmolb.2020.00160
ISSN/ISBN:		2296-889X (Print) 2296-889X (Electronic) 2296-889X (Linking)
Abstract:		"Gene duplications are a feature of bacterial genomes. In the present work we analyze the extent of gene duplications in the genomes of three microorganisms that belong to the Firmicutes phylum and that are etiologic agents of several nosocomial infections: Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis. In all three groups, there is an irregular distribution of duplications in the genomes of the strains analyzed. Whereas in some of the strains duplications are scarce, hundreds of duplications are present in others. In all three species, mobile DNA accounts for a large percentage of the duplicated genes: phage DNA in S. aureus, and plasmid DNA in the enterococci. Duplicates also include core genes. In all three species, a reduced group of genes is duplicated in all strains analyzed. Duplication of the deoC and rpmG genes is a hallmark of S. aureus genomes. Duplication of the gene encoding the PTS IIB subunit is detected in all enterococci genomes. In E. faecalis it is remarkable that the genomes of some strains encode duplicates of the prgB and prgU genes. They belong to the prgABCU cluster, which responds to the presence of the peptide pheromone cCF10 by expressing the surface adhesins PrgA, PrgB, and PrgC"
Keywords:		Enterococcus faecalis Enterococcus faecium Staphylococcus aureus bacterial genomics gene duplication;
Notes:		"PubMed-not-MEDLINESanchez-Herrero, Jose Francisco Bernabeu, Manuel Prieto, Alejandro Huttener, Mario Juarez, Antonio eng Switzerland 2020/08/28 Front Mol Biosci. 2020 Jul 23; 7:160. doi: 10.3389/fmolb.2020.00160. eCollection 2020"