| Title: | Analysis of the volatile organic compounds of epidural analgesia-ameliorated metabolic disorder in pregnant women with gestational diabetes mellitus based on untargeted metabolomics |
| Author(s): | Sana S; Lv Y; Chen G; Guo L; Li E; |
| Address: | "Department of Anesthesiology, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China" |
| Journal Title: | Front Endocrinol (Lausanne) |
| DOI: | 10.3389/fendo.2023.1009888 |
| ISSN/ISBN: | 1664-2392 (Print) 1664-2392 (Electronic) 1664-2392 (Linking) |
| Abstract: | "Gestational diabetes mellitus (GDM) is a metabolic disease with an increasing annual incidence. Our previous observational study found that pregnant women with gestational diabetes had mild cognitive decline, which may be related to methylglyoxal (MGO). This study aimed to investigate whether labor pain aggravates the increase in MGO and explored the protective effect of epidural analgesia on metabolism in pregnant women with GDM based on solid-phase microextraction gas chromatography/mass spectrometry (SPME/GC-MS). Pregnant women with GDM were divided into a natural birth group (ND group, n = 30) and epidural analgesia group (PD group, n = 30). After fasting for >/= 10 h overnight, venous blood samples were collected pre- and post-delivery to detect MGO, interleukin-6 (IL-6), and 8-epi-prostaglandin F2 alpha (8-iso-PGF2alpha) by ELISA. Serum samples were analyzed for volatile organic compounds (VOCs) using SPME-GC-MS. MGO, IL-6, and 8-iso-PGF2alpha levels in the ND group increased significantly post-delivery (P < 0.05) and were significantly higher in this group than the levels in the PD group (P < 0.05). Compared to the PD group, VOCs in the ND group increased significantly post-delivery. Further results indicated that propionic acid may be associated with metabolic disorders in pregnant women with GDM. Epidural analgesia can effectively improve the metabolism and immune function in pregnant women with GDM" |
| Keywords: | "Female Humans Pregnancy *Analgesia, Epidural/adverse effects *Diabetes, Gestational Interleukin-6 Magnesium Oxide Metabolomics Pyruvaldehyde *Volatile Organic Compounds/adverse effects epidural analgesia gestational diabetes mellitus humoral biomarkers so;" |
| Notes: | "MedlineSana, Si Ri Gu Leng Lv, Yang Chen, Guangmin Guo, Lei Li, Enyou eng Observational Study Research Support, Non-U.S. Gov't Switzerland 2023/03/04 Front Endocrinol (Lausanne). 2023 Feb 14; 14:1009888. doi: 10.3389/fendo.2023.1009888. eCollection 2023" |
