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Front Med (Lausanne)

Title:		Macrophage Exposure to Polycyclic Aromatic Hydrocarbons From Wood Smoke Reduces the Ability to Control Growth of Mycobacterium tuberculosis
Author(s):		Sada-Ovalle I; Chavez-Galan L; Vasquez L; Aldriguetti S; Rosas-Perez I; Ramirez-Venegas A; Perez-Padilla R; Torre-Bouscoulet L;
Address:		"Laboratorio de Inmunologia Integrativa, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Ciudad de Mexico, Mexico. Departamento de Ciencias Ambientales, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico. Departmento de Tabaquismo, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Ciudad de Mexico, Mexico. Medica Sur, Clinic and Foundation, Mexico City, Mexico"
Journal Title:		Front Med (Lausanne)
Year:		2018
Volume:		20181113
Issue:
Page Number:		309 -
DOI:		10.3389/fmed.2018.00309
ISSN/ISBN:		2296-858X (Print) 2296-858X (Electronic) 2296-858X (Linking)
Abstract:		"Use of solid fuels for cooking or home heating has been related to various diseases of the respiratory tract. Woodsmoke contains a mixture of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds. Inhalation of these materials induces local and systemic changes in the immune system which may impair critical cell defense mechanisms; however, few studies have investigated the early effects that PAH exposures have on immune cells as macrophages. The aim of this study was to analyze if the pre-exposure to PAHs derived from woodsmoke deteriorates macrophage ability to control the intracellular growth of Mycobacterium tuberculosis. By using an in vitro experimental model, we analyzed the phenotype and some metabolic changes on THP-1 and monocyte-derived macrophages. Our results demonstrated that exposure to PAHs leads to cell activation and deteriorates mitochondrial function of the macrophage thus facilitating growth of M. tuberculosis"
Keywords:		PAHs macrophages mitochondrial disfunction organic extracts tuberculosis;
Notes:		"PubMed-not-MEDLINESada-Ovalle, Isabel Chavez-Galan, Leslie Vasquez, Luis Aldriguetti, Stepahnie Rosas-Perez, Irma Ramirez-Venegas, Alejandra Perez-Padilla, Rogelio Torre-Bouscoulet, Luis eng Switzerland 2018/11/30 Front Med (Lausanne). 2018 Nov 13; 5:309. doi: 10.3389/fmed.2018.00309. eCollection 2018"