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Rev Environ Health

Title:		Exposure to persistent organic pollutants during tooth formation: molecular mechanisms and clinical findings
Author(s):		Bianchi S; Bernardi S; Belli M; Varvara G; Macchiarelli G;
Address:		"Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. Microscopy Centre, Universiyt of L'Aquila, L'Aquila, Italy. Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy"
Journal Title:		Rev Environ Health
Year:		2020
Volume:		20200417
Issue:		4
Page Number:		303 - 310
DOI:		10.1515/reveh-2019-0093
ISSN/ISBN:		2191-0308 (Electronic) 0048-7554 (Linking)
Abstract:		"Persistent organic pollutants (POPs) constitute a relevant part of environmental pollution. POPs are chemical compounds that persist for a long time in the environment, bio-accumulate in the human body and determine significant adverse consequences to human health. The characteristics of these substances are lipo-affinity, semi-volatility and resistance to the degradation processes. Results deriving from several different studies attest that exposure to the main classes of POPs results in multiple toxic effects on humans and experimental animal models. Among the various alterations caused by exposition to and bio-accumulation of POPs, there are abnormalities in tooth formation and related hard dental tissue structure, especially enamel. This review aimed to describe the close association between the exposure of these compounds during the development of the tooth germ and the occurrence of tooth structural anomalies. Indeed, structural defects of the enamel have as possible consequences higher susceptibility of the tooth to caries disease and higher fragility of the crown to the occlusal trauma"
Keywords:		Humans Odontogenesis/*drug effects Persistent Organic Pollutants/*adverse effects developmental enamel defects environmental exposure persistent organic pollutants;
Notes:		"MedlineBianchi, Serena Bernardi, Sara Belli, Manuel Varvara, Giuseppe Macchiarelli, Guido eng Review Germany 2020/04/19 Rev Environ Health. 2020 Apr 17; 35(4):303-310. doi: 10.1515/reveh-2019-0093. Print 2020 Nov 18"