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FEMS Yeast Res

Title:		Expression of HPV16 E6 oncoprotein increases resistance to several stress conditions in Saccharomyces cerevisiae
Author(s):		Pinto-de-Oliveira A; McCance D; de Magalhaes-Sant'Ana AC; Marques JM; Goncalves T;
Address:		"Centre for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal"
Journal Title:		FEMS Yeast Res
Year:		2005
Volume:		5
Issue:		8
Page Number:		777 - 787
DOI:		10.1016/j.femsyr.2005.02.002
ISSN/ISBN:		1567-1356 (Print) 1567-1356 (Linking)
Abstract:		"The E6 protein of human papillomavirus type 16 is essential for the oncogenic transformation process induced by these viruses. Here we expressed the E6 protein in Saccharomyces cerevisiae (which lacks p53) in order to determine if E6 interacts with normal cell functioning, independently of the p53 tumour suppressor factor. We observed a higher resistance to caffeine, hydrogen peroxide and to pheromone, but not to high temperature, starvation and osmostress. Measurement of the relative expression levels of target genes of the signalling pathways, involved in the latter stressful stimuli, led us to conclude that such pathways are differently regulated in the presence of E6"
Keywords:		"Caffeine Gene Expression Regulation, Fungal Hydrogen Peroxide Oncogene Proteins, Viral/genetics/*metabolism Osmotic Pressure Oxidative Stress Pheromones Protein-Tyrosine Kinases/*metabolism Repressor Proteins/genetics/*metabolism Saccharomyces cerevisiae/;neuroscience;"
Notes:		"MedlinePinto-de-Oliveira, Ana McCance, Dennis de Magalhaes-Sant'Ana, Augusto C Marques, Joana M Goncalves, Teresa eng England 2005/04/27 FEMS Yeast Res. 2005 May; 5(8):777-87. doi: 10.1016/j.femsyr.2005.02.002"