| Title: | Bioproducts generation from carboxylate platforms by the non-conventional yeast Yarrowia lipolytica |
| Author(s): | Park YK; Gonzalez-Fernandez C; Robles-Iglesias R; Vidal L; Fontanille P; Kennes C; Tomas Pejo E; Nicaud JM; Fickers P; |
| Address: | "Micalis Institute, Universite Paris-Saclay, INRAE, AgroParisTech, Jouy-en-Josas, France. Biotechnological Processes Unit, IMDEA Energy, Avenida Ramon De La Sagra, 3. 28935, Mostoles, Madrid, Spain. Chemical Engineering Laboratory, Faculty of Sciences and Center for Advanced Scientific Research (CICA), BIOENGIN group, University of La Coruna, Rua da Fraga 10, E-15008 La Coruna, Spain. Institut Pascal UMR CNRS 6602, Polytech Clermont-Ferrand, Universite Clermont Auvergne (UCA), F-63178 Aubiere, France. Microbial Processes and Interactions, TERRA Teaching and Research Centre, University of Liege - Gembloux Agro-Bio Tech, 5030 Gembloux, Belgium" |
| ISSN/ISBN: | 1567-1364 (Electronic) 1567-1356 (Linking) |
| Abstract: | "In recent years, there has been a growing interest in the use of renewable sources for bio-based production aiming at developing sustainable and feasible approaches towards a circular economy. Among these renewable sources, organic wastes (OWs) can be anaerobically digested to generate carboxylates like volatile fatty acids (VFAs), lactic acid, and longer-chain fatty acids that are regarded as novel building blocks for the synthesis of value-added compounds by yeasts. This review discusses on the processes that can be used to create valuable molecules from OW-derived VFAs; the pathways employed by the oleaginous yeast Yarrowia lipolytica to directly metabolize such molecules; and the relationship between OW composition, anaerobic digestion, and VFA profiles. The review also summarizes the current knowledge about VFA toxicity, the pathways by which VFAs are metabolized and the metabolic engineering strategies that can be employed in Y. lipolytica to produce value-added biobased compounds from VFAs" |
| Keywords: | "Carboxylic Acids Fatty Acids Fatty Acids, Volatile Metabolic Engineering *Yarrowia/genetics Yarrowia lipolytica anaerobic digestion bioproduction organic waste volatile fatty acids waste valorization;" |
| Notes: | "MedlinePark, Young-Kyoung Gonzalez-Fernandez, Cristina Robles-Iglesias, Raul Vidal, Lea Fontanille, Pierre Kennes, Christian Tomas Pejo, Elia Nicaud, Jean-Marc Fickers, Patrick eng ANR-20-CE43-0007/ANR/ European Cooperation in Science and Technology/ PID2020-117805-RB/Spanish Ministry of Science and Innovation/ Research Support, Non-U.S. Gov't Review England 2021/08/29 FEMS Yeast Res. 2021 Sep 11; 21(6):foab047. doi: 10.1093/femsyr/foab047" |
