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FEBS Lett

Title:		Apparent inhibition of glycoprotein synthesis by S.cerevisiae mating pheromones
Author(s):		Orlean P; Arnold E; Tanner W;
Address:
Journal Title:		FEBS Lett
Year:		1985
Volume:		184
Issue:		2
Page Number:		313 - 317
DOI:		10.1016/0014-5793(85)80629-3
ISSN/ISBN:		0014-5793 (Print) 0014-5793 (Linking)
Abstract:		"Saccharomyces cerevisiae mating pheromones a and alpha factor strongly inhibit the incorporation of radiolabelled glucosamine into N-glycosylated proteins of corresponding haploid cells. This observation was erroneously interpreted as an inhibition of glycoprotein synthesis. It has turned out that alpha factor causes a 4-5-fold dilution of incorporated [14C]glucosamine with non-radioactive endogenous precursor. In the case of the [14C]chitin synthesized, which does not show inhibition by alpha factor, the lowering of the specific activity of the precursor is exactly compensated for by an increased rate of chitin synthesis caused by alpha factor"
Keywords:		Animals Chitin/biosynthesis Glucosamine/metabolism Glycoproteins/*biosynthesis Mating Factor Peptides/*pharmacology Pheromones/pharmacology Saccharomyces cerevisiae/*physiology;
Notes:		"MedlineOrlean, P Arnold, E Tanner, W eng Research Support, Non-U.S. Gov't England 1985/05/20 FEBS Lett. 1985 May 20; 184(2):313-7. doi: 10.1016/0014-5793(85)80629-3"