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FEMS Yeast Res

Title:		"In Candida albicans, resistance to flucytosine and terbinafine is linked to MAT locus homozygosity and multilocus sequence typing clade 1"
Author(s):		Odds FC;
Address:		"Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK. f.odds@abdn.ac.uk"
Journal Title:		FEMS Yeast Res
Year:		2009
Volume:		20090907
Issue:		7
Page Number:		1091 - 1101
DOI:		10.1111/j.1567-1364.2009.00577.x
ISSN/ISBN:		1567-1364 (Electronic) 1567-1356 (Linking)
Abstract:		"A panel of 637 isolates of Candida albicans that had been typed by multilocus sequence typing (MLST) and tested for susceptibility to amphotericin B, caspofungin, fluconazole, flucytosine, itraconazole, ketoconazole, miconazole, terbinafine and voriconazole was the material for a statistical analysis of possible associations between antifungal susceptibility and other properties. For terbinafine and flucytosine, the greatest proportion of low-susceptibility isolates, judged by two resistance breakpoints, was found in MLST clade 1 and among isolates homozygous at the MAT locus, although only three isolates showed cross-resistance to the two agents. Most instances of low susceptibility to azoles, flucytosine and terbinafine were among oropharyngeal isolates from HIV-positive individuals. Statistically significant correlations were found between terbinafine and azole minimal inhibitory concentrations (MICs), while correlations between flucytosine MICs and azole MICs were less strong. It is concluded that a common regulatory mechanism may operate to generate resistance to the two classes of agent that inhibit ergosterol biosynthesis, terbinafine and the azoles, but that flucytosine resistance, although still commonly associated with MAT homozygosity, is differently regulated"
Keywords:		"Antifungal Agents/*pharmacology Candida albicans/classification/*drug effects/*genetics/isolation & purification Candidiasis/microbiology DNA Fingerprinting *Drug Resistance, Fungal Flucytosine/*pharmacology Genotype HIV Infections/complications Homozygot;"
Notes:		"MedlineOdds, Frank C eng England 2009/10/06 FEMS Yeast Res. 2009 Oct; 9(7):1091-101. doi: 10.1111/j.1567-1364.2009.00577.x. Epub 2009 Sep 7"