| Title: | How neurogenesis finds its place in a hardwired sensory system |
| Address: | "Children's National Health System, Center for Neuroscience Research Washington, DC, USA. Department of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri Ottolenghi, University of Torino Orbassano, Italy" |
| ISSN/ISBN: | 1662-4548 (Print) 1662-453X (Electronic) 1662-453X (Linking) |
| Abstract: | "So far most studies on adult neurogenesis aimed to unravel mechanisms and molecules regulating the integration of newly generated neurons in the mature brain parenchyma. The exceedingly abundant amount of results that followed, rather than being beneficial in the perspective of brain repair, provided a clear evidence that adult neurogenesis constitutes a necessary feature to the correct functioning of the hosting brain regions. In particular, the rodent olfactory system represents a privileged model to study how neuronal plasticity and neurogenesis interact with sensory functions. Until recently, the vomeronasal system (VNS) has been commonly described as being specialized in the detection of innate chemosignals. Accordingly, its circuitry has been considered necessarily stable, if not hard-wired, in order to allow stereotyped behavioral responses. However, both first and second order projections of the rodent VNS continuously change their synaptic connectivity due to ongoing postnatal and adult neurogenesis. How the functional integrity of a neuronal circuit is maintained while newborn neurons are continuously added-or lost-is a fundamental question for both basic and applied neuroscience. The VNS is proposed as an alternative model to answer such question. Hereby the underlying motivations will be reviewed" |
| Keywords: | Aob Vno accessory olfactory bulb innate neurogenesis pheromones plasticity vomeronasal;neuroscience; |
| Notes: | "PubMed-not-MEDLINEOboti, Livio Peretto, Paolo eng Review Switzerland 2014/05/23 Front Neurosci. 2014 May 9; 8:102. doi: 10.3389/fnins.2014.00102. eCollection 2014" |
