| Title: | Detection of Pancreatic Cancer by Urine Volatile Organic Compound Analysis |
| Author(s): | Nissinen SI; Roine A; Hokkinen L; Karjalainen M; Venalainen M; Helminen H; Niemi R; Lehtimaki T; Rantanen T; Oksala N; |
| Address: | "School of Medicine, University of Eastern Finland, Kuopio, Finland samuli.nissinen@gmail.com. Department of Gastroenterology, Kuopio University Hospital, Kuopio, Finland. Department of Surgery, Hatanpaa Hospital, Tampere, Finland. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland. School of Medicine, University of Eastern Finland, Kuopio, Finland. Seinajoki Central Hospital, Seinajoki, Finland. Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Finnish Cardiovascular Research Center Tampere, Tampere, Finland. Department of Surgery, Kuopio University Hospital, Kuopio, Finland. Department of Vascular Surgery, Tampere University Hospital, Tampere, Finland" |
| DOI: | 10.21873/anticanres.13081 |
| ISSN/ISBN: | 1791-7530 (Electronic) 0250-7005 (Linking) |
| Abstract: | "BACKGROUND/AIM: Most pancreatic cancer patients are diagnosed at an advanced stage, since the diagnosis is demanding. Field asymmetric waveform ion mobility spectrometry (FAIMS) is a sensitive technique used for the detection of volatile organic compounds (VOC). We evaluated the ability of FAIMS to discriminate between pancreatic cancer and healthy controls from a urine sample. PATIENTS AND METHODS: For a proof-of-concept study in three Finnish hospitals, 68 patients with pancreatic cancer, 36 with acute pancreatitis, 18 with chronic pancreatitis, 8 with pancreatic pre-malign lesions and 52 healthy controls were prospectively recruited. Urine samples were collected at the time of diagnosis and stored at -70 degrees C. The samples were subsequently measured with FAIMS. The data were processed with linear discriminant analysis and cross-validated with leave-one-out cross-validation. RESULTS: FAIMS distinguished pancreatic cancer from controls with a sensitivity of 79% and specificity of 79%. CONCLUSION: As a non-invasive and rapid urine test, FAIMS can discriminate patients with pancreatic cancer from healthy controls" |
| Keywords: | Aged Female Humans Ion Mobility Spectrometry/methods Male Middle Aged Pancreatic Neoplasms/pathology/*urine Precancerous Conditions/pathology/*urine Urinalysis/methods Volatile Organic Compounds/isolation & purification/*urine Faims Pancreatic cancer line; |
| Notes: | "MedlineNissinen, Samuli I Roine, Antti Hokkinen, Lauri Karjalainen, Markus Venalainen, Markus Helminen, Heli Niemi, Riikka Lehtimaki, Terho Rantanen, Tuomo Oksala, Niku eng Greece 2018/12/29 Anticancer Res. 2019 Jan; 39(1):73-79. doi: 10.21873/anticanres.13081" |
