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Front Vet Sci

Title:		Non-invasive cancer detection in canine urine through Caenorhabditis elegans chemotaxis
Author(s):		Namgong C; Kim JH; Lee MH; Midkiff D;
Address:		"Animal Cancer Dx, Raleigh, NC, United States. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States. IntelligentComparative Oncology Lab, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States. Division of Hematology/Oncology, Department of Internal Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, United States"
Journal Title:		Front Vet Sci
Year:		2022
Volume:		20220809
Issue:
Page Number:		932474 -
DOI:		10.3389/fvets.2022.932474
ISSN/ISBN:		2297-1769 (Print) 2297-1769 (Electronic) 2297-1769 (Linking)
Abstract:		"Cancer is the leading cause of death in companion animals, and successful early treatment has been a challenge in the veterinary field. We have developed the Non-Invasive Cancer Screening (N.C.S.) Study to perform cancer detection through the analysis of canine urine samples. The test makes use of the strong olfactory system of the nematode Caenorhabditis elegans, which was previously shown to positively respond to urine samples from human cancer patients. We performed a proof-of-concept study to optimize the detection capability in urine samples obtained from dogs with naturally occurring cancers. In this study, we established a scale for identifying the cancer risk based on the magnitude of the chemotaxis index of C. elegans toward a canine urine sample. Through validation, the N.C.S. Study achieved a sensitivity of 85%, showing that it is highly sensitive to indicate the presence of cancer across multiple types of common canine cancers. The test also showed a 90% specificity to cancer samples, indicating a low rate of over-identifying cancer risk. From these results, we have demonstrated the ability to perform low-cost, non-invasive cancer detection in companion animals-a method that can increase the ability to perform cancer diagnosis and treatment"
Keywords:		Caenorhabditis elegans cancer detection chemotaxis olfaction volatile organic compounds;
Notes:		"PubMed-not-MEDLINENamgong, Chan Kim, Jong Hyuk Lee, Myon Hee Midkiff, Daniel eng Switzerland 2022/08/27 Front Vet Sci. 2022 Aug 9; 9:932474. doi: 10.3389/fvets.2022.932474. eCollection 2022"