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Sci Rep

Title:		Multivariate Optimization of Tenax TA-Thermal Extraction for Determining Gaseous Phase Organophosphate Esters in Air Samples
Author(s):		Matsiko J; Li H; Wang P; Sun H; Zheng S; Wang D; Zhang W; Hao Y; Zuo P; Li Y; Zhang Q; Zhang J; Jiang G;
Address:		"State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. University of Chinese Academy of Sciences, Beijing, 100049, China. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. qhzhang@rcees.ac.cn. University of Chinese Academy of Sciences, Beijing, 100049, China. qhzhang@rcees.ac.cn. Institute of Environment and Health, Jianghan University, Wuhan, 430056, China. qhzhang@rcees.ac.cn. Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China. 969676617@qq.com"
Journal Title:		Sci Rep
Year:		2019
Volume:		20190304
Issue:		1
Page Number:		3330 -
DOI:		10.1038/s41598-019-40119-2
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Suitable conditions for thermal extraction of semi-volatile organic compounds have largely been arrived at by univariate optimization or based on the recommendations provided by the manufacturers of the extraction equipment. Herein, we demonstrated the multivariate optimization of Tenax TA-thermal extraction for determining organophosphate esters in the gas phase fraction of air samples. Screening and refining experiments were performed using the eighth fraction factorial and Box-Behnken designs, respectively, and satisfactory models were obtained. Subsequently, the process was optimized by Derringer's desirability function and the global desirability was 0.7299. Following optimization, the analytes were desorbed at 290 degrees C for 10 minutes at a helium flow of 95 mL min(-1), with the transfer line set at 290 degrees C. The analytes were then cryofocused at 20 degrees C and then cryodesorbed into the chromatographic column at 295 degrees C for 6 minutes. Method validation exhibited high linearity coefficients (>0.99), good precision (CV < 14%) and low detection limits (0.1-0.5 ng m(-3)). The method was tested by pumping 0.024 m(3) of real indoor environment air through Tenax TA sorbent tubes. Furthermore, with multivariate optimization, analysis time and other resources were significantly reduced, and information about experimental factor interaction effects was investigated, as compared to the univariate optimization and other traditional methods"
Keywords:
Notes:		"PubMed-not-MEDLINEMatsiko, Julius Li, Honghua Wang, Pu Sun, Huizhong Zheng, Shucheng Wang, Dou Zhang, Weiwei Hao, Yanfen Zuo, Peijie Li, Yingming Zhang, Qinghua Zhang, Jianqing Jiang, Guibin eng Research Support, Non-U.S. Gov't England 2019/03/06 Sci Rep. 2019 Mar 4; 9(1):3330. doi: 10.1038/s41598-019-40119-2"