| Title: | Noninvasive detection of soft tissue sarcoma using volatile organic compounds in exhaled breath: a pilot study |
| Author(s): | Acem I; van Praag VM; Mostert CQ; van der Wal RJ; Neijenhuis RM; Verhoef C; Grunhagen DJ; van de Sande MA; |
| Address: | "Department of Surgical Oncology & Gastrointestinal Surgery, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, Rotterdam, 3015, GD, The Netherlands. Department of Orthopedic Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands" |
| ISSN/ISBN: | 1744-8301 (Electronic) 1479-6694 (Linking) |
| Abstract: | "Aim: The aim of this pilot study was to assess whether an electronic nose can detect patients with soft tissue sarcoma (STS) based on volatile organic compound profiles in exhaled breath. Patients & methods: In this cross-sectional pilot study, patients with primary STS and healthy controls, matched on sex and age, were included for breath analysis. Machine learning techniques were used to develop the best-fitting model. Results: Fifty-nine breath samples were collected (29 STS and 30 control) from March 2018 to March 2022. The final model yielded a c-statistic of 0.85 with a sensitivity of 83% and specificity of 60%. Conclusion: This study suggests that exhaled volatile organic compound analysis could serve as a noninvasive diagnostic biomarker for the detection of STS with a good performance. Diagnosing soft tissue sarcoma (STS) among the large number of benign soft tissue tumors is challenging. There is a serious need for a novel and easy tool that could accurately detect patients with STS. This study aimed to assess how well an easy-to-use electronic nose could differentiate between patients with STS and those without STS based on their exhaled breath. This is the first pilot study to reveal that an electronic nose could serve as a diagnostic tool for the detection of STS with a good performance. Future studies are needed to validate the findings in larger cohorts. eng" |
| Keywords: | Humans *Volatile Organic Compounds/analysis Pilot Projects Cross-Sectional Studies *Sarcoma/diagnosis Breath Tests/methods Electronic Nose breath analysis diagnostic test soft tissue sarcoma volatile organic compounds; |
| Notes: | "MedlineAcem, Ibtissam van Praag, Veroniek M Mostert, Cassidy Qb van der Wal, Robert Jp Neijenhuis, Ralph Ml Verhoef, Cornelis Grunhagen, Dirk J van de Sande, Michiel Aj eng England 2023/05/02 Future Oncol. 2023 Mar; 19(10):697-704. doi: 10.2217/fon-2022-1122. Epub 2023 May 2" |
