« Previous AbstractGas barrier film with a compositional gradient interface prepared by plasma modification of an organic/inorganic hybrid sol-gel coat    Next AbstractIntracellular distribution of pregnenolone metabolites in testis of macaque (Macaca fascicularis) »

FEBS Lett

Title:		Biosynthesis of androgens and pheromonal steroids in neonatal porcine testicular preparations
Author(s):		Kwan TK; Orengo C; Gower DB;
Address:
Journal Title:		FEBS Lett
Year:		1985
Volume:		183
Issue:		2
Page Number:		359 - 364
DOI:		10.1016/0014-5793(85)80810-3
ISSN/ISBN:		0014-5793 (Print) 0014-5793 (Linking)
Abstract:		"The biosynthesis of testosterone and 4-androstene-3,17-dione and some 16-androstenes has been studied in homogenates or subcellular fractions of testes from 3-week-old Landrace piglets. Pregnenolone was converted into 5,16-androstadien-3 beta-ol, 4,16-androstadien-3-one, 5 alpha-androst-16-en-3-one and 5 alpha-androst-16-en-3 alpha- and 3 beta-ols, but the quantities were some 50 times less than those formed in the mature boar testis. Androgens were also formed in the microsomal fractions but the quantities of 4-androstene-3,17-dione (from side-chain cleavage of 17-hydroxyprogesterone) and of testosterone (from reduction of 4-androstene-3,17-dione) were 50-70 times lower than in the adult animal. The kinetic parameters and cofactor preference of the 3 alpha- and 3 beta-hydroxysteroid dehydrogenases were determined in the cytosolic, microsomal and mitochondrial fractions of neonatal porcine testes"
Keywords:		"17-Hydroxysteroid Dehydrogenases/metabolism 3-Hydroxysteroid Dehydrogenases/metabolism Androgens/*biosynthesis Androstenes/metabolism Animals Animals, Newborn/*metabolism Kinetics Male Pheromones/*biosynthesis Pregnenolone/metabolism Swine Testis/*metabol;"
Notes:		"MedlineKwan, T K Orengo, C Gower, D B eng Research Support, Non-U.S. Gov't England 1985/04/22 FEBS Lett. 1985 Apr 22; 183(2):359-64. doi: 10.1016/0014-5793(85)80810-3"