| Title: | Biological effects of crude oil vapor. IV. Cardiovascular effects |
| Author(s): | Krajnak K; Russ KA; McKinney W; Waugh S; Zheng W; Kan H; Kashon ML; Cumpston J; Fedan JS; |
| Address: | "Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America. Electronic address: ksk1@cdc.gov. Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America" |
| DOI: | 10.1016/j.taap.2022.116071 |
| ISSN/ISBN: | 1096-0333 (Electronic) 0041-008X (Print) 0041-008X (Linking) |
| Abstract: | "Workers in the oil and gas extraction industry are at risk of inhaling volatile organic compounds. Epidemiological studies suggest oil vapor inhalation may affect cardiovascular health. Thus, in this hazard identification study we investigated the effects of inhalation of crude oil vapor (COV) on cardiovascular function. Male rats were exposed to air or COV (300 ppm) for 6 h (acute), or 6 h/day x 4 d/wk. x 4 wk. (sub-chronic). The effects of COV inhalation were assessed 1, 28, and 90 d post-exposure. Acute exposure to COV resulted in reductions in mean arterial and diastolic blood pressures 1 and 28 d after exposure, changes in nitrate-nitrite and H(2)O(2) levels, and in the expression of transcripts and proteins that regulate inflammation, vascular remodeling, and the synthesis of nitric oxide (NO) in the heart and kidneys. The sub-chronic exposure resulted in a reduced sensitivity to alpha(1)-adrenoreceptor-mediated vasoconstriction in vitro 28 d post-exposure, and a reduction in oxidative stress in the heart. Sub-chronic COV exposure led to alterations in the expression of NO synthases and anti-oxidant enzymes, which regulate inflammation and oxidative stress in the heart and kidneys. There seems to be a balance between changes in the expression of transcripts associated with the generation of reactive oxygen species (ROS) and antioxidant enzymes. The ability of antioxidant enzymes to reduce or inhibit the effects of ROS may allow the cardiovascular system to adapt to acute COV exposures. However, sub-chronic exposures may result in longer-lasting negative health consequences on the cardiovascular system" |
| Keywords: | Animals Antioxidants/metabolism/pharmacology *Cardiovascular System/metabolism Gases/pharmacology Hydrogen Peroxide/pharmacology Inflammation Inhalation Exposure/adverse effects Male Oxidative Stress *Petroleum Rats Reactive Oxygen Species/metabolism Adre; |
| Notes: | "MedlineKrajnak, Kristine Russ, Kristen A McKinney, Walter Waugh, Stacey Zheng, Wen Kan, Hong Kashon, Michael L Cumpston, Jared Fedan, Jeffrey S eng CC999999/ImCDC/Intramural CDC HHS/ Research Support, U.S. Gov't, P.H.S. 2022/05/23 Toxicol Appl Pharmacol. 2022 Jul 15; 447:116071. doi: 10.1016/j.taap.2022.116071. Epub 2022 May 20" |
