| Title: | Genetic analysis of SecA-SecY interaction required for spore development in Bacillus subtilis |
| Author(s): | Kobayashi H; Ohashi Y; Nanamiya H; Asai K; Kawamura F; |
| Address: | "Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, Toshima-ku, Tokyo, Japan" |
| DOI: | 10.1111/j.1574-6968.2000.tb09028.x |
| ISSN/ISBN: | 0378-1097 (Print) 0378-1097 (Linking) |
| Abstract: | "All spontaneous suppressor mutations obtained from a secA12 sporulation-defective mutant in Bacillus subtilis were localized in highly conserved membrane-spanning regions of SecY. The expression of early sporulation genes, kinA and spo0A encoding a histidine kinase and a transcription regulator for several sporulation genes, respectively, was restored in these suppressor mutants. These results indicate that the secretion function of translocase combined with Sec proteins is required for sporulation in B. subtilis" |
| Keywords: | "*ATP-Binding Cassette Transporters Adenosine Triphosphatases/genetics/*metabolism Bacillus subtilis/genetics/*physiology Bacterial Proteins/genetics/*metabolism Carrier Proteins/genetics/*metabolism *Escherichia coli Proteins Gene Expression Regulation, B;" |
| Notes: | "MedlineKobayashi, H Ohashi, Y Nanamiya, H Asai, K Kawamura, F eng Research Support, Non-U.S. Gov't England 2000/03/14 FEMS Microbiol Lett. 2000 Mar 15; 184(2):285-9. doi: 10.1111/j.1574-6968.2000.tb09028.x" |
