| Title: | "Decreased Numbers of CD4(+) Naive and Effector Memory T Cells, and CD8(+) Naive T Cells, are Associated with Trichloroethylene Exposure" |
| Author(s): | Hosgood HD; Zhang L; Tang X; Vermeulen R; Qiu C; Shen M; Smith MT; Ge Y; Ji Z; Xiong J; He J; Reiss B; Liu S; Xie Y; Guo W; Galvan N; Li L; Hao Z; Rothman N; Huang H; Lan Q; |
| Address: | "Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, MD, USA" |
| ISSN/ISBN: | 2234-943X (Electronic) 2234-943X (Linking) |
| Abstract: | "Trichloroethylene (TCE) is a volatile chlorinated organic compound that is commonly used as a solvent for lipophilic compounds. Although recognized as an animal carcinogen, TCE's carcinogenic potential in humans is still uncertain. We have carried out a cross-sectional study of 80 workers exposed to TCE and 96 unexposed controls matched on age and sex in Guangdong, China to study TCE's early biologic effects. We previously reported that the total lymphocyte count and each of the major lymphocyte subsets (i.e., CD4(+) T cells, CD8(+) T cells, natural killer cells, and B cells) were decreased in TCE-exposed workers compared to controls, suggesting a selective effect on lymphoid progenitors, and/or lymphocyte survival. To explore which T lymphocyte subsets are affected in the same study population, we investigated the effect of TCE exposure on the numbers of CD4(+) naive and memory T cells, CD8(+) naive and memory T cells, and regulatory T cells by FACS analysis. Linear regression of each subset was used to test for differences between exposed workers and controls adjusting for potential confounders. We observed that CD4(+) and CD8(+) naive T cell counts were about 8% (p = 0.056) and 17% (p = 0.0002) lower, respectively, among exposed workers. CD4(+) effector memory T cell counts were decreased by about 20% among TCE-exposed workers compared to controls (p = 0.001). The selective targeting of TCE on CD8(+) naive and possibly CD4(+) naive T cells, and CD4(+) effector memory T cells, provide further insights into the immunosuppression-related response of human immune cells upon TCE exposure" |
| Keywords: | Cd4 Cd8 lymphocyte memory naive trichloroethylene; |
| Notes: | "PubMed-not-MEDLINEHosgood, H Dean 3rd Zhang, Luoping Tang, Xiaojiang Vermeulen, Roel Qiu, Chuangyi Shen, Min Smith, Martyn T Ge, Yichen Ji, Zhiying Xiong, Jun He, Jian Reiss, Boris Liu, Songwang Xie, Yuxuan Guo, Weihong Galvan, Noe Li, Laiyu Hao, Zhenyue Rothman, Nathaniel Huang, Hanlin Lan, Qing eng P30 ES001896/ES/NIEHS NIH HHS/ P42 ES004705/ES/NIEHS NIH HHS/ Switzerland 2011/01/01 Front Oncol. 2012 Jan 10; 1:53. doi: 10.3389/fonc.2011.00053. eCollection 2011" |
