| Title: | NHERF1 in Microvilli of Vomeronasal Sensory Neurons |
| Author(s): | Henkel B; Bintig W; Bhat SS; Spehr M; Neuhaus EM; |
| Address: | "Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University Jena, Drackendorfer Strasse 1, 07743 Jena, Germany. Cluster of Excellence NeuroCure, Charite-Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany and. Present address: Institute of Anatomy, Medical Faculty, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Present address: Institute of Biochemistry, Charite-Universitatsmedizin Berlin, Berlin, Germany. Department of Chemosensation, Institute for Biology II, RWTH-Aachen University, Worringerweg 3, 52074 Aachen, Germany. Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University Jena, Drackendorfer Strasse 1, 07743 Jena, Germany, eva.neuhaus@med.uni-jena.de" |
| ISSN/ISBN: | 1464-3553 (Electronic) 0379-864X (Linking) |
| Abstract: | "In most mammals, the vomeronasal system detects a variety of (semio)chemicals that mediate olfactory-driven social and sexual behaviors. Vomeronasal chemosensation depends on G protein-coupled receptors (V1R, V2R, and FPR-rs) that operate at remarkably low stimulus concentrations, thus, indicating a highly sensitive and efficient signaling pathway. We identified the PDZ domain-containing protein, Na(+)/H(+) exchanger regulatory factor-1 (NHERF1), as putative molecular organizer of signal transduction in vomeronasal neurons. NHERF1 is a protein that contains 2 PDZ domains and a carboxy-terminal ezrin-binding domain. It localizes to microvilli of vomeronasal sensory neurons and interacts with V1Rs. Furthermore, NHERF1 and Galpha(i2) are closely colocalized. These findings open up new aspects of the functional organization and regulation of vomeronasal signal transduction by PDZ scaffolding proteins" |
| Keywords: | "Animals Mice Mice, Inbred C57BL Microvilli/*chemistry/metabolism Phosphoproteins/*analysis/genetics/metabolism Sensory Receptor Cells/*chemistry/metabolism Sodium-Hydrogen Exchangers/*analysis/genetics/metabolism Vomeronasal Organ/*cytology Nherf1 Pdz V1r;" |
| Notes: | "MedlineHenkel, Bastian Bintig, Willem Bhat, S Sneha Spehr, Marc Neuhaus, Eva M eng Research Support, Non-U.S. Gov't England 2016/09/23 Chem Senses. 2017 Jan; 42(1):25-35. doi: 10.1093/chemse/bjw094. Epub 2016 Sep 21" |
