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Front Physiol

Title:		Effect of Cigarette Smoke on Gut Microbiota: State of Knowledge
Author(s):		Gui X; Yang Z; Li MD;
Address:		"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, China"
Journal Title:		Front Physiol
Year:		2021
Volume:		20210617
Issue:
Page Number:		673341 -
DOI:		10.3389/fphys.2021.673341
ISSN/ISBN:		1664-042X (Print) 1664-042X (Electronic) 1664-042X (Linking)
Abstract:		"Cigarette smoke is a representative source of toxic chemical exposures to humans, and the adverse consequences of cigarette smoking are mediated by its effect on both neuronal and immune-inflammatory systems. Cigarette smoking also is a major risk factor for intestinal disorders, such as Crohn's disease and peptic ulcer. On the other hand, cigarette smoking is protective against developing ulcerative colitis. The effects of cigarette smoking on intestinal disorders include changes in intestinal irrigation and microbiome, increases in permeability of the mucosa, and impaired mucosal immune responses. However, the underlying mechanism linking cigarette smoking with intestinal microbiota dysbiosis is largely unknown. In this communication, we first review the current knowledge about the mechanistic interaction between cigarette smoke and intestinal microbiota dysbiosis, which include the likely actions of nicotine, aldehydes, polycyclic aromatic hydrocarbons, heavy metals, volatile organic compounds and toxic gases, and then reveal the potential mechanisms of the lung-gut cross talk and skin-gut cross talk in regulating the balance of intestinal microbiota and the interrelation of intestinal microbiota dysbiosis and systemic disorders"
Keywords:		cigarette smoking intestinal microbiota dysbiosis lung-gut axis skin-gut axis systemic disorders;
Notes:		"PubMed-not-MEDLINEGui, Xiaohua Yang, Zhongli Li, Ming D eng Review Switzerland 2021/07/06 Front Physiol. 2021 Jun 17; 12:673341. doi: 10.3389/fphys.2021.673341. eCollection 2021"